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Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics

Gold nanomaterials (Au NMs) have been widely used in cosmetic products for improving the brightening, and reducing the wrinkling of, skin, etc.; however, the dermal safety of Au NMs is rarely concerned. A previous study found that cosmetics could enhance the toxicity of Au nanosheets, but different...

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Autores principales: Liu, Chusheng, Wang, Yanjing, Zhang, Gaofei, Pang, Xuebin, Yan, Jiao, Wu, Xiaoou, Qiu, Yingheng, Wang, Ping, Huang, Houshuang, Wang, Xiaowei, Zhang, Haiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228324/
https://www.ncbi.nlm.nih.gov/pubmed/35736885
http://dx.doi.org/10.3390/toxics10060276
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author Liu, Chusheng
Wang, Yanjing
Zhang, Gaofei
Pang, Xuebin
Yan, Jiao
Wu, Xiaoou
Qiu, Yingheng
Wang, Ping
Huang, Houshuang
Wang, Xiaowei
Zhang, Haiyuan
author_facet Liu, Chusheng
Wang, Yanjing
Zhang, Gaofei
Pang, Xuebin
Yan, Jiao
Wu, Xiaoou
Qiu, Yingheng
Wang, Ping
Huang, Houshuang
Wang, Xiaowei
Zhang, Haiyuan
author_sort Liu, Chusheng
collection PubMed
description Gold nanomaterials (Au NMs) have been widely used in cosmetic products for improving the brightening, and reducing the wrinkling of, skin, etc.; however, the dermal safety of Au NMs is rarely concerned. A previous study found that cosmetics could enhance the toxicity of Au nanosheets, but different physicochemical properties of Au NMs will induce different interaction modes with ingredients of cosmetics, potentially leading to different toxicity profiles. In the present study, spherical and rodlike Au NMs were first found in commercial cosmetics, and then Au nanospheres (NSs) with different sizes and Au nanorods (NRs) with different aspect ratios were prepared to simulate these Au NMs in cosmetics and further investigate their toxicity before and after embedment in cosmetics. It was found that the primary sizes, morphologies, and optical absorptions of these Au NSs and NRs before and after embedment were similar; however, their hydrodynamic sizes and zeta potentials were noticeably different. Then, these Au NSs and NRs presented weak or no cytotoxicity against HaCaT keratinocytes, while cosmetic cream could alleviate their cytotoxicity. Moreover, the cream could enhance the accumulation of Au NSs and NRs in the skin of hairless mice, but it also alleviated the toxicological responses of Au NSs and NRs in terms of superoxide dismutase (SOD) elevation and malondialdehyde (MDA) reduction. Therefore, the embedment of Au NSs and NRs into cosmetics can alleviate the in vitro and in vivo dermal toxicities of Au NSs and NRs.
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spelling pubmed-92283242022-06-25 Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics Liu, Chusheng Wang, Yanjing Zhang, Gaofei Pang, Xuebin Yan, Jiao Wu, Xiaoou Qiu, Yingheng Wang, Ping Huang, Houshuang Wang, Xiaowei Zhang, Haiyuan Toxics Article Gold nanomaterials (Au NMs) have been widely used in cosmetic products for improving the brightening, and reducing the wrinkling of, skin, etc.; however, the dermal safety of Au NMs is rarely concerned. A previous study found that cosmetics could enhance the toxicity of Au nanosheets, but different physicochemical properties of Au NMs will induce different interaction modes with ingredients of cosmetics, potentially leading to different toxicity profiles. In the present study, spherical and rodlike Au NMs were first found in commercial cosmetics, and then Au nanospheres (NSs) with different sizes and Au nanorods (NRs) with different aspect ratios were prepared to simulate these Au NMs in cosmetics and further investigate their toxicity before and after embedment in cosmetics. It was found that the primary sizes, morphologies, and optical absorptions of these Au NSs and NRs before and after embedment were similar; however, their hydrodynamic sizes and zeta potentials were noticeably different. Then, these Au NSs and NRs presented weak or no cytotoxicity against HaCaT keratinocytes, while cosmetic cream could alleviate their cytotoxicity. Moreover, the cream could enhance the accumulation of Au NSs and NRs in the skin of hairless mice, but it also alleviated the toxicological responses of Au NSs and NRs in terms of superoxide dismutase (SOD) elevation and malondialdehyde (MDA) reduction. Therefore, the embedment of Au NSs and NRs into cosmetics can alleviate the in vitro and in vivo dermal toxicities of Au NSs and NRs. MDPI 2022-05-24 /pmc/articles/PMC9228324/ /pubmed/35736885 http://dx.doi.org/10.3390/toxics10060276 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Chusheng
Wang, Yanjing
Zhang, Gaofei
Pang, Xuebin
Yan, Jiao
Wu, Xiaoou
Qiu, Yingheng
Wang, Ping
Huang, Houshuang
Wang, Xiaowei
Zhang, Haiyuan
Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics
title Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics
title_full Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics
title_fullStr Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics
title_full_unstemmed Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics
title_short Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics
title_sort dermal toxicity influence of gold nanomaterials after embedment in cosmetics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228324/
https://www.ncbi.nlm.nih.gov/pubmed/35736885
http://dx.doi.org/10.3390/toxics10060276
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