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Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design

Coronavirus disease-2019 (COVID-19) is a pandemic with a high morbidity rate occurring over recent years. COVID-19 is caused by the severe acute respiratory syndrome causing coronavirus type-2 (SARS-CoV-2). COVID-19 not only challenged mankind but also gave scope to the evolution of various vaccine...

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Autores principales: Addala, Santhinissi, Vissapragada, Madhuri, Aggunna, Madhumita, Mukala, Niharikha, Lanka, Manisha, Gampa, Shyamkumar, Sodasani, Manikanta, Chintalapati, Jahnavi, Kamidi, Akhila, Veeranna, Ravindra P., Yedidi, Ravikiran S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228374/
https://www.ncbi.nlm.nih.gov/pubmed/35746449
http://dx.doi.org/10.3390/vaccines10060841
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author Addala, Santhinissi
Vissapragada, Madhuri
Aggunna, Madhumita
Mukala, Niharikha
Lanka, Manisha
Gampa, Shyamkumar
Sodasani, Manikanta
Chintalapati, Jahnavi
Kamidi, Akhila
Veeranna, Ravindra P.
Yedidi, Ravikiran S.
author_facet Addala, Santhinissi
Vissapragada, Madhuri
Aggunna, Madhumita
Mukala, Niharikha
Lanka, Manisha
Gampa, Shyamkumar
Sodasani, Manikanta
Chintalapati, Jahnavi
Kamidi, Akhila
Veeranna, Ravindra P.
Yedidi, Ravikiran S.
author_sort Addala, Santhinissi
collection PubMed
description Coronavirus disease-2019 (COVID-19) is a pandemic with a high morbidity rate occurring over recent years. COVID-19 is caused by the severe acute respiratory syndrome causing coronavirus type-2 (SARS-CoV-2). COVID-19 not only challenged mankind but also gave scope to the evolution of various vaccine design technologies. Although these vaccines protected and saved many lives, with the emerging viral strains, some of the strains may pose a threat to the currently existing vaccine design that is primarily based on the wild type spike protein of SARS-CoV-2. To evaluate the risk involved from such mutant viral strains, we performed a systematic in silico amino acid substitution of critical residues in the receptor binding domain (RBD) of the spike protein. Our molecular modeling analysis revealed significant topological changes in the RBD of spike protein suggesting that they could potentially contribute to the loss of antigen specificity for the currently existing therapeutic antibodies/vaccines, thus posing a challenge to the current vaccine strategies that are based on wild type viral spike protein epitopes. The structural deviations discussed in this article should be considered carefully in the future vaccine design.
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spelling pubmed-92283742022-06-25 Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design Addala, Santhinissi Vissapragada, Madhuri Aggunna, Madhumita Mukala, Niharikha Lanka, Manisha Gampa, Shyamkumar Sodasani, Manikanta Chintalapati, Jahnavi Kamidi, Akhila Veeranna, Ravindra P. Yedidi, Ravikiran S. Vaccines (Basel) Article Coronavirus disease-2019 (COVID-19) is a pandemic with a high morbidity rate occurring over recent years. COVID-19 is caused by the severe acute respiratory syndrome causing coronavirus type-2 (SARS-CoV-2). COVID-19 not only challenged mankind but also gave scope to the evolution of various vaccine design technologies. Although these vaccines protected and saved many lives, with the emerging viral strains, some of the strains may pose a threat to the currently existing vaccine design that is primarily based on the wild type spike protein of SARS-CoV-2. To evaluate the risk involved from such mutant viral strains, we performed a systematic in silico amino acid substitution of critical residues in the receptor binding domain (RBD) of the spike protein. Our molecular modeling analysis revealed significant topological changes in the RBD of spike protein suggesting that they could potentially contribute to the loss of antigen specificity for the currently existing therapeutic antibodies/vaccines, thus posing a challenge to the current vaccine strategies that are based on wild type viral spike protein epitopes. The structural deviations discussed in this article should be considered carefully in the future vaccine design. MDPI 2022-05-25 /pmc/articles/PMC9228374/ /pubmed/35746449 http://dx.doi.org/10.3390/vaccines10060841 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Addala, Santhinissi
Vissapragada, Madhuri
Aggunna, Madhumita
Mukala, Niharikha
Lanka, Manisha
Gampa, Shyamkumar
Sodasani, Manikanta
Chintalapati, Jahnavi
Kamidi, Akhila
Veeranna, Ravindra P.
Yedidi, Ravikiran S.
Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design
title Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design
title_full Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design
title_fullStr Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design
title_full_unstemmed Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design
title_short Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design
title_sort success of current covid-19 vaccine strategies vs. the epitope topology of sars-cov-2 spike protein-receptor binding domain (rbd): a computational study of rbd topology to guide future vaccine design
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228374/
https://www.ncbi.nlm.nih.gov/pubmed/35746449
http://dx.doi.org/10.3390/vaccines10060841
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