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Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities

Aquacultured fish are the richest natural source of protein. However, their overproduced biomass is often discarded due to production imbalance, causing considerable losses to the fishery industry. Therefore, it is necessary to utilize surplus fish and add value to overproduced fish. We performed co...

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Autores principales: Lee, Hyo-Geun, Oh, Jae-Young, Chung, Dong-Min, Seo, Min-Young, Park, Shin-Jae, Jeon, You-Jin, Ryu, Bo-Mi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228416/
https://www.ncbi.nlm.nih.gov/pubmed/35736148
http://dx.doi.org/10.3390/md20060346
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author Lee, Hyo-Geun
Oh, Jae-Young
Chung, Dong-Min
Seo, Min-Young
Park, Shin-Jae
Jeon, You-Jin
Ryu, Bo-Mi
author_facet Lee, Hyo-Geun
Oh, Jae-Young
Chung, Dong-Min
Seo, Min-Young
Park, Shin-Jae
Jeon, You-Jin
Ryu, Bo-Mi
author_sort Lee, Hyo-Geun
collection PubMed
description Aquacultured fish are the richest natural source of protein. However, their overproduced biomass is often discarded due to production imbalance, causing considerable losses to the fishery industry. Therefore, it is necessary to utilize surplus fish and add value to overproduced fish. We performed complex enzyme-assisted hydrolysis to determine the correlation between its physical characteristics and anti-hypertensive activity in vitro and in vivo using an SHR model. Protamex-Pepsin assisted hydrolysate from Paralichthys olivaceus (PO(pp)H) produced by complex enzyme-assisted hydrolysis contained low-molecular-weight peptides and amino acids with anti-hypertensive activity. PO(pp)H regulated blood pressure and serum angiotensin II and angiotensin-I-converting enzyme levels, and histological and ultrasound image analysis revealed substantially reduced thickness and diameter of the carotid aorta in the PO(pp)H-administered SHR group. Therefore, we propose to reduce food loss due to overproduction by utilizing the anti-hypertensive activity and physical properties of PO(pp)H; the results demonstrate its application as a therapeutic agent.
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spelling pubmed-92284162022-06-25 Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities Lee, Hyo-Geun Oh, Jae-Young Chung, Dong-Min Seo, Min-Young Park, Shin-Jae Jeon, You-Jin Ryu, Bo-Mi Mar Drugs Article Aquacultured fish are the richest natural source of protein. However, their overproduced biomass is often discarded due to production imbalance, causing considerable losses to the fishery industry. Therefore, it is necessary to utilize surplus fish and add value to overproduced fish. We performed complex enzyme-assisted hydrolysis to determine the correlation between its physical characteristics and anti-hypertensive activity in vitro and in vivo using an SHR model. Protamex-Pepsin assisted hydrolysate from Paralichthys olivaceus (PO(pp)H) produced by complex enzyme-assisted hydrolysis contained low-molecular-weight peptides and amino acids with anti-hypertensive activity. PO(pp)H regulated blood pressure and serum angiotensin II and angiotensin-I-converting enzyme levels, and histological and ultrasound image analysis revealed substantially reduced thickness and diameter of the carotid aorta in the PO(pp)H-administered SHR group. Therefore, we propose to reduce food loss due to overproduction by utilizing the anti-hypertensive activity and physical properties of PO(pp)H; the results demonstrate its application as a therapeutic agent. MDPI 2022-05-25 /pmc/articles/PMC9228416/ /pubmed/35736148 http://dx.doi.org/10.3390/md20060346 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Hyo-Geun
Oh, Jae-Young
Chung, Dong-Min
Seo, Min-Young
Park, Shin-Jae
Jeon, You-Jin
Ryu, Bo-Mi
Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities
title Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities
title_full Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities
title_fullStr Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities
title_full_unstemmed Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities
title_short Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities
title_sort utility of a hydrolysate from overproduced paralichthys olivaceus for hypertension treatment: correlation between physical properties and potent anti-hypertensive activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228416/
https://www.ncbi.nlm.nih.gov/pubmed/35736148
http://dx.doi.org/10.3390/md20060346
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