Cargando…

Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women

Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear. We aimed to assess the relationships betw...

Descripción completa

Detalles Bibliográficos
Autores principales: Stefanska, Anna, Bergmann, Katarzyna, Krintus, Magdalena, Kuligowska-Prusinska, Magdalena, Murawska, Karolina, Sypniewska, Grazyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228451/
https://www.ncbi.nlm.nih.gov/pubmed/35736472
http://dx.doi.org/10.3390/metabo12060539
_version_ 1784734478833287168
author Stefanska, Anna
Bergmann, Katarzyna
Krintus, Magdalena
Kuligowska-Prusinska, Magdalena
Murawska, Karolina
Sypniewska, Grazyna
author_facet Stefanska, Anna
Bergmann, Katarzyna
Krintus, Magdalena
Kuligowska-Prusinska, Magdalena
Murawska, Karolina
Sypniewska, Grazyna
author_sort Stefanska, Anna
collection PubMed
description Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear. We aimed to assess the relationships between serum ANGPTL3 and ANGPTL8 and atherogenic biomarkers in presumably healthy women during ageing. The study group included 94 women of whom 31 were premenopausal (PRE ≤ 40 years) and 37 were postmenopausal (POST ≥ 52 years). Atherogenic lipid and non-lipid biomarkers and ANGPTLs (ANGPTL3, ANGPTL8) were assayed in serum samples. TG/HDL-C index, non-HDL-cholesterol, remnant cholesterol concentrations, and BMI were calculated. Median levels of ANGPTL3 and concentrations of lipid biomarkers were significantly higher in POST comparing to PRE but ANGPTL8 levels were not different. In PRE, ANGPTL8 levels correlated significantly with TG and TG/HDL-C index while there were no correlations between ANGPTL3 and these biomarkers. In POST both ANGPTLs correlated with TG, sdLDL-C, and TG/HDL-C. ANGPTL8 and sd-LDL-C were the most significant predictors of early triglyceride elevation > 100 mg/dL (1.13 mmol/L) in the whole group and POST whereas the prediction power of ANGPTL3 was negligible in the whole group and non-significant in the subgroups. We demonstrated a significant positive correlation of ANGPTL3 with age category which predisposes to postmenopause. Despite the increase in ANGPTL3 level with ageing the ANGPTL3/ANGPL8 ratio was maintained. In conclusion, ANGPTL8 predicts the early triglyceride elevation better than ANGPTL3, especially in postmenopausal women. The association of ANGPTL3 with triglyceride levels is weaker than ANGPTL8 and depends on menopausal status. We suggest that the choice for the best efficient treatment of dyslipidemia with new inhibitors of angiopoietin-like proteins may depend on the menopausal status.
format Online
Article
Text
id pubmed-9228451
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92284512022-06-25 Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women Stefanska, Anna Bergmann, Katarzyna Krintus, Magdalena Kuligowska-Prusinska, Magdalena Murawska, Karolina Sypniewska, Grazyna Metabolites Article Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear. We aimed to assess the relationships between serum ANGPTL3 and ANGPTL8 and atherogenic biomarkers in presumably healthy women during ageing. The study group included 94 women of whom 31 were premenopausal (PRE ≤ 40 years) and 37 were postmenopausal (POST ≥ 52 years). Atherogenic lipid and non-lipid biomarkers and ANGPTLs (ANGPTL3, ANGPTL8) were assayed in serum samples. TG/HDL-C index, non-HDL-cholesterol, remnant cholesterol concentrations, and BMI were calculated. Median levels of ANGPTL3 and concentrations of lipid biomarkers were significantly higher in POST comparing to PRE but ANGPTL8 levels were not different. In PRE, ANGPTL8 levels correlated significantly with TG and TG/HDL-C index while there were no correlations between ANGPTL3 and these biomarkers. In POST both ANGPTLs correlated with TG, sdLDL-C, and TG/HDL-C. ANGPTL8 and sd-LDL-C were the most significant predictors of early triglyceride elevation > 100 mg/dL (1.13 mmol/L) in the whole group and POST whereas the prediction power of ANGPTL3 was negligible in the whole group and non-significant in the subgroups. We demonstrated a significant positive correlation of ANGPTL3 with age category which predisposes to postmenopause. Despite the increase in ANGPTL3 level with ageing the ANGPTL3/ANGPL8 ratio was maintained. In conclusion, ANGPTL8 predicts the early triglyceride elevation better than ANGPTL3, especially in postmenopausal women. The association of ANGPTL3 with triglyceride levels is weaker than ANGPTL8 and depends on menopausal status. We suggest that the choice for the best efficient treatment of dyslipidemia with new inhibitors of angiopoietin-like proteins may depend on the menopausal status. MDPI 2022-06-11 /pmc/articles/PMC9228451/ /pubmed/35736472 http://dx.doi.org/10.3390/metabo12060539 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stefanska, Anna
Bergmann, Katarzyna
Krintus, Magdalena
Kuligowska-Prusinska, Magdalena
Murawska, Karolina
Sypniewska, Grazyna
Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
title Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
title_full Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
title_fullStr Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
title_full_unstemmed Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
title_short Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
title_sort serum angptl8 and angptl3 as predictors of triglyceride elevation in adult women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228451/
https://www.ncbi.nlm.nih.gov/pubmed/35736472
http://dx.doi.org/10.3390/metabo12060539
work_keys_str_mv AT stefanskaanna serumangptl8andangptl3aspredictorsoftriglycerideelevationinadultwomen
AT bergmannkatarzyna serumangptl8andangptl3aspredictorsoftriglycerideelevationinadultwomen
AT krintusmagdalena serumangptl8andangptl3aspredictorsoftriglycerideelevationinadultwomen
AT kuligowskaprusinskamagdalena serumangptl8andangptl3aspredictorsoftriglycerideelevationinadultwomen
AT murawskakarolina serumangptl8andangptl3aspredictorsoftriglycerideelevationinadultwomen
AT sypniewskagrazyna serumangptl8andangptl3aspredictorsoftriglycerideelevationinadultwomen