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Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women
Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear. We aimed to assess the relationships betw...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228451/ https://www.ncbi.nlm.nih.gov/pubmed/35736472 http://dx.doi.org/10.3390/metabo12060539 |
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author | Stefanska, Anna Bergmann, Katarzyna Krintus, Magdalena Kuligowska-Prusinska, Magdalena Murawska, Karolina Sypniewska, Grazyna |
author_facet | Stefanska, Anna Bergmann, Katarzyna Krintus, Magdalena Kuligowska-Prusinska, Magdalena Murawska, Karolina Sypniewska, Grazyna |
author_sort | Stefanska, Anna |
collection | PubMed |
description | Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear. We aimed to assess the relationships between serum ANGPTL3 and ANGPTL8 and atherogenic biomarkers in presumably healthy women during ageing. The study group included 94 women of whom 31 were premenopausal (PRE ≤ 40 years) and 37 were postmenopausal (POST ≥ 52 years). Atherogenic lipid and non-lipid biomarkers and ANGPTLs (ANGPTL3, ANGPTL8) were assayed in serum samples. TG/HDL-C index, non-HDL-cholesterol, remnant cholesterol concentrations, and BMI were calculated. Median levels of ANGPTL3 and concentrations of lipid biomarkers were significantly higher in POST comparing to PRE but ANGPTL8 levels were not different. In PRE, ANGPTL8 levels correlated significantly with TG and TG/HDL-C index while there were no correlations between ANGPTL3 and these biomarkers. In POST both ANGPTLs correlated with TG, sdLDL-C, and TG/HDL-C. ANGPTL8 and sd-LDL-C were the most significant predictors of early triglyceride elevation > 100 mg/dL (1.13 mmol/L) in the whole group and POST whereas the prediction power of ANGPTL3 was negligible in the whole group and non-significant in the subgroups. We demonstrated a significant positive correlation of ANGPTL3 with age category which predisposes to postmenopause. Despite the increase in ANGPTL3 level with ageing the ANGPTL3/ANGPL8 ratio was maintained. In conclusion, ANGPTL8 predicts the early triglyceride elevation better than ANGPTL3, especially in postmenopausal women. The association of ANGPTL3 with triglyceride levels is weaker than ANGPTL8 and depends on menopausal status. We suggest that the choice for the best efficient treatment of dyslipidemia with new inhibitors of angiopoietin-like proteins may depend on the menopausal status. |
format | Online Article Text |
id | pubmed-9228451 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92284512022-06-25 Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women Stefanska, Anna Bergmann, Katarzyna Krintus, Magdalena Kuligowska-Prusinska, Magdalena Murawska, Karolina Sypniewska, Grazyna Metabolites Article Angiopoietin-like proteins ANGPTL3 and ANGPTL8 have been shown to inhibit lipoprotein lipase, and thus regulate triglyceride level in the circulation. Whether the regulation of lipid metabolism by ANGPTLs is affected by the menopausal status remains unclear. We aimed to assess the relationships between serum ANGPTL3 and ANGPTL8 and atherogenic biomarkers in presumably healthy women during ageing. The study group included 94 women of whom 31 were premenopausal (PRE ≤ 40 years) and 37 were postmenopausal (POST ≥ 52 years). Atherogenic lipid and non-lipid biomarkers and ANGPTLs (ANGPTL3, ANGPTL8) were assayed in serum samples. TG/HDL-C index, non-HDL-cholesterol, remnant cholesterol concentrations, and BMI were calculated. Median levels of ANGPTL3 and concentrations of lipid biomarkers were significantly higher in POST comparing to PRE but ANGPTL8 levels were not different. In PRE, ANGPTL8 levels correlated significantly with TG and TG/HDL-C index while there were no correlations between ANGPTL3 and these biomarkers. In POST both ANGPTLs correlated with TG, sdLDL-C, and TG/HDL-C. ANGPTL8 and sd-LDL-C were the most significant predictors of early triglyceride elevation > 100 mg/dL (1.13 mmol/L) in the whole group and POST whereas the prediction power of ANGPTL3 was negligible in the whole group and non-significant in the subgroups. We demonstrated a significant positive correlation of ANGPTL3 with age category which predisposes to postmenopause. Despite the increase in ANGPTL3 level with ageing the ANGPTL3/ANGPL8 ratio was maintained. In conclusion, ANGPTL8 predicts the early triglyceride elevation better than ANGPTL3, especially in postmenopausal women. The association of ANGPTL3 with triglyceride levels is weaker than ANGPTL8 and depends on menopausal status. We suggest that the choice for the best efficient treatment of dyslipidemia with new inhibitors of angiopoietin-like proteins may depend on the menopausal status. MDPI 2022-06-11 /pmc/articles/PMC9228451/ /pubmed/35736472 http://dx.doi.org/10.3390/metabo12060539 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Stefanska, Anna Bergmann, Katarzyna Krintus, Magdalena Kuligowska-Prusinska, Magdalena Murawska, Karolina Sypniewska, Grazyna Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women |
title | Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women |
title_full | Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women |
title_fullStr | Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women |
title_full_unstemmed | Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women |
title_short | Serum ANGPTL8 and ANGPTL3 as Predictors of Triglyceride Elevation in Adult Women |
title_sort | serum angptl8 and angptl3 as predictors of triglyceride elevation in adult women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228451/ https://www.ncbi.nlm.nih.gov/pubmed/35736472 http://dx.doi.org/10.3390/metabo12060539 |
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