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The Phospholipase Activity of Ammodytoxin, a Prototype Snake Venom β-Neurotoxin, Is Not Obligatory for Cell Internalisation and Translocation to Mitochondria

β-Neurotoxins are secreted phospholipase A(2) molecules that inhibit transmission in neuromuscular synapses by poisoning the motor neurons. These toxins specifically and rapidly internalise into the nerve endings of motor neurons. Ammodytoxin (Atx) is a prototype β-neurotoxin from the venom of the n...

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Detalles Bibliográficos
Autores principales: Ivanušec, Adrijan, Šribar, Jernej, Veranič, Peter, Križaj, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228470/
https://www.ncbi.nlm.nih.gov/pubmed/35737036
http://dx.doi.org/10.3390/toxins14060375