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Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children

Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that ta...

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Autores principales: Hagenbeek, Fiona A., van Dongen, Jenny, Pool, René, Harms, Amy C., Roetman, Peter J., Fanos, Vassilios, van Keulen, Britt J., Walker, Brian R., Karu, Naama, Hulshoff Pol, Hilleke E., Rotteveel, Joost, Finken, Martijn J. J., Vermeiren, Robert R. J. M., Kluft, Cornelis, Bartels, Meike, Hankemeier, Thomas, Boomsma, Dorret I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228478/
https://www.ncbi.nlm.nih.gov/pubmed/35736407
http://dx.doi.org/10.3390/metabo12060474
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author Hagenbeek, Fiona A.
van Dongen, Jenny
Pool, René
Harms, Amy C.
Roetman, Peter J.
Fanos, Vassilios
van Keulen, Britt J.
Walker, Brian R.
Karu, Naama
Hulshoff Pol, Hilleke E.
Rotteveel, Joost
Finken, Martijn J. J.
Vermeiren, Robert R. J. M.
Kluft, Cornelis
Bartels, Meike
Hankemeier, Thomas
Boomsma, Dorret I.
author_facet Hagenbeek, Fiona A.
van Dongen, Jenny
Pool, René
Harms, Amy C.
Roetman, Peter J.
Fanos, Vassilios
van Keulen, Britt J.
Walker, Brian R.
Karu, Naama
Hulshoff Pol, Hilleke E.
Rotteveel, Joost
Finken, Martijn J. J.
Vermeiren, Robert R. J. M.
Kluft, Cornelis
Bartels, Meike
Hankemeier, Thomas
Boomsma, Dorret I.
author_sort Hagenbeek, Fiona A.
collection PubMed
description Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7–12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the urinary metabolites indicated a role for non-additive genetic factors for 50 amines, 13 organic acids, and 6 steroids. The average broad-sense heritability for these amines, organic acids, and steroids was 0.49 (range: 0.25–0.64), 0.50 (range: 0.33–0.62), and 0.64 (range: 0.43–0.81), respectively. For 6 amines, 7 organic acids, and 4 steroids the twin correlations indicated a role for shared environmental factors and the average narrow-sense heritability was 0.50 (range: 0.37–0.68), 0.50 (range; 0.23–0.61), and 0.47 (range: 0.32–0.70) for these amines, organic acids, and steroids. We conclude that urinary metabolites in children have substantial heritability, with similar estimates for amines and organic acids, and higher estimates for steroid hormones.
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spelling pubmed-92284782022-06-25 Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children Hagenbeek, Fiona A. van Dongen, Jenny Pool, René Harms, Amy C. Roetman, Peter J. Fanos, Vassilios van Keulen, Britt J. Walker, Brian R. Karu, Naama Hulshoff Pol, Hilleke E. Rotteveel, Joost Finken, Martijn J. J. Vermeiren, Robert R. J. M. Kluft, Cornelis Bartels, Meike Hankemeier, Thomas Boomsma, Dorret I. Metabolites Article Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7–12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the urinary metabolites indicated a role for non-additive genetic factors for 50 amines, 13 organic acids, and 6 steroids. The average broad-sense heritability for these amines, organic acids, and steroids was 0.49 (range: 0.25–0.64), 0.50 (range: 0.33–0.62), and 0.64 (range: 0.43–0.81), respectively. For 6 amines, 7 organic acids, and 4 steroids the twin correlations indicated a role for shared environmental factors and the average narrow-sense heritability was 0.50 (range: 0.37–0.68), 0.50 (range; 0.23–0.61), and 0.47 (range: 0.32–0.70) for these amines, organic acids, and steroids. We conclude that urinary metabolites in children have substantial heritability, with similar estimates for amines and organic acids, and higher estimates for steroid hormones. MDPI 2022-05-24 /pmc/articles/PMC9228478/ /pubmed/35736407 http://dx.doi.org/10.3390/metabo12060474 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hagenbeek, Fiona A.
van Dongen, Jenny
Pool, René
Harms, Amy C.
Roetman, Peter J.
Fanos, Vassilios
van Keulen, Britt J.
Walker, Brian R.
Karu, Naama
Hulshoff Pol, Hilleke E.
Rotteveel, Joost
Finken, Martijn J. J.
Vermeiren, Robert R. J. M.
Kluft, Cornelis
Bartels, Meike
Hankemeier, Thomas
Boomsma, Dorret I.
Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children
title Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children
title_full Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children
title_fullStr Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children
title_full_unstemmed Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children
title_short Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children
title_sort heritability of urinary amines, organic acids, and steroid hormones in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228478/
https://www.ncbi.nlm.nih.gov/pubmed/35736407
http://dx.doi.org/10.3390/metabo12060474
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