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Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics
The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228483/ https://www.ncbi.nlm.nih.gov/pubmed/35744496 http://dx.doi.org/10.3390/mi13060881 |
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author | Madadelahi, Masoud Azimi-Boulali, Javid Madou, Marc Martinez-Chapa, Sergio Omar |
author_facet | Madadelahi, Masoud Azimi-Boulali, Javid Madou, Marc Martinez-Chapa, Sergio Omar |
author_sort | Madadelahi, Masoud |
collection | PubMed |
description | The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally, we employ theoretical models to show how liquid polymeric droplets pass a fluidic barrier before crosslinking. We explain how secondary flows evolve and mix the fluids within the droplets. From an experimental point of view, the effect of different parameters, such as the barrier length, source channel width, and rotational speed, on the particles’ size and aspect ratio are investigated. It is demonstrated that the barrier length does not affect the particle’s ultimate velocity. Unlike conventional air gaps, the barrier length does not significantly affect the aspect ratio of the produced microparticles. Eventually, we broaden this concept to two source fluids and study the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets. |
format | Online Article Text |
id | pubmed-9228483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92284832022-06-25 Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics Madadelahi, Masoud Azimi-Boulali, Javid Madou, Marc Martinez-Chapa, Sergio Omar Micromachines (Basel) Article The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally, we employ theoretical models to show how liquid polymeric droplets pass a fluidic barrier before crosslinking. We explain how secondary flows evolve and mix the fluids within the droplets. From an experimental point of view, the effect of different parameters, such as the barrier length, source channel width, and rotational speed, on the particles’ size and aspect ratio are investigated. It is demonstrated that the barrier length does not affect the particle’s ultimate velocity. Unlike conventional air gaps, the barrier length does not significantly affect the aspect ratio of the produced microparticles. Eventually, we broaden this concept to two source fluids and study the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets. MDPI 2022-05-31 /pmc/articles/PMC9228483/ /pubmed/35744496 http://dx.doi.org/10.3390/mi13060881 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Madadelahi, Masoud Azimi-Boulali, Javid Madou, Marc Martinez-Chapa, Sergio Omar Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
title | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
title_full | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
title_fullStr | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
title_full_unstemmed | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
title_short | Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics |
title_sort | characterization of fluidic-barrier-based particle generation in centrifugal microfluidics |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228483/ https://www.ncbi.nlm.nih.gov/pubmed/35744496 http://dx.doi.org/10.3390/mi13060881 |
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