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Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics

The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally,...

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Detalles Bibliográficos
Autores principales: Madadelahi, Masoud, Azimi-Boulali, Javid, Madou, Marc, Martinez-Chapa, Sergio Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228483/
https://www.ncbi.nlm.nih.gov/pubmed/35744496
http://dx.doi.org/10.3390/mi13060881
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author Madadelahi, Masoud
Azimi-Boulali, Javid
Madou, Marc
Martinez-Chapa, Sergio Omar
author_facet Madadelahi, Masoud
Azimi-Boulali, Javid
Madou, Marc
Martinez-Chapa, Sergio Omar
author_sort Madadelahi, Masoud
collection PubMed
description The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally, we employ theoretical models to show how liquid polymeric droplets pass a fluidic barrier before crosslinking. We explain how secondary flows evolve and mix the fluids within the droplets. From an experimental point of view, the effect of different parameters, such as the barrier length, source channel width, and rotational speed, on the particles’ size and aspect ratio are investigated. It is demonstrated that the barrier length does not affect the particle’s ultimate velocity. Unlike conventional air gaps, the barrier length does not significantly affect the aspect ratio of the produced microparticles. Eventually, we broaden this concept to two source fluids and study the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets.
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spelling pubmed-92284832022-06-25 Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics Madadelahi, Masoud Azimi-Boulali, Javid Madou, Marc Martinez-Chapa, Sergio Omar Micromachines (Basel) Article The fluidic barrier in centrifugal microfluidic platforms is a newly introduced concept for making multiple emulsions and microparticles. In this study, we focused on particle generation application to better characterize this method. Because the phenomenon is too fast to be captured experimentally, we employ theoretical models to show how liquid polymeric droplets pass a fluidic barrier before crosslinking. We explain how secondary flows evolve and mix the fluids within the droplets. From an experimental point of view, the effect of different parameters, such as the barrier length, source channel width, and rotational speed, on the particles’ size and aspect ratio are investigated. It is demonstrated that the barrier length does not affect the particle’s ultimate velocity. Unlike conventional air gaps, the barrier length does not significantly affect the aspect ratio of the produced microparticles. Eventually, we broaden this concept to two source fluids and study the importance of source channel geometry, barrier length, and rotational speed in generating two-fluid droplets. MDPI 2022-05-31 /pmc/articles/PMC9228483/ /pubmed/35744496 http://dx.doi.org/10.3390/mi13060881 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Madadelahi, Masoud
Azimi-Boulali, Javid
Madou, Marc
Martinez-Chapa, Sergio Omar
Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics
title Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics
title_full Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics
title_fullStr Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics
title_full_unstemmed Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics
title_short Characterization of Fluidic-Barrier-Based Particle Generation in Centrifugal Microfluidics
title_sort characterization of fluidic-barrier-based particle generation in centrifugal microfluidics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228483/
https://www.ncbi.nlm.nih.gov/pubmed/35744496
http://dx.doi.org/10.3390/mi13060881
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