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The Virus–Host Interplay in Junín Mammarenavirus Infection

Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina. At this moment, there are no effective antiviral therapeutics to battle pathogenic arenaviruses. Cumulative report...

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Detalles Bibliográficos
Autores principales: Gallo, Giovanna Lucrecia, López, Nora, Loureiro, María Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228484/
https://www.ncbi.nlm.nih.gov/pubmed/35746604
http://dx.doi.org/10.3390/v14061134
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author Gallo, Giovanna Lucrecia
López, Nora
Loureiro, María Eugenia
author_facet Gallo, Giovanna Lucrecia
López, Nora
Loureiro, María Eugenia
author_sort Gallo, Giovanna Lucrecia
collection PubMed
description Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina. At this moment, there are no effective antiviral therapeutics to battle pathogenic arenaviruses. Cumulative reports from recent years have widely provided information on cellular factors playing key roles during JUNV infection. In this review, we summarize research on host molecular determinants that intervene in the different stages of the viral life cycle: viral entry, replication, assembly and budding. Alongside, we describe JUNV tight interplay with the innate immune system. We also review the development of different reverse genetics systems and their use as tools to study JUNV biology and its close teamwork with the host. Elucidating relevant interactions of the virus with the host cell machinery is highly necessary to better understand the mechanistic basis beyond virus multiplication, disease pathogenesis and viral subversion of the immune response. Altogether, this knowledge becomes essential for identifying potential targets for the rational design of novel antiviral treatments to combat JUNV as well as other pathogenic arenaviruses.
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spelling pubmed-92284842022-06-25 The Virus–Host Interplay in Junín Mammarenavirus Infection Gallo, Giovanna Lucrecia López, Nora Loureiro, María Eugenia Viruses Review Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina. At this moment, there are no effective antiviral therapeutics to battle pathogenic arenaviruses. Cumulative reports from recent years have widely provided information on cellular factors playing key roles during JUNV infection. In this review, we summarize research on host molecular determinants that intervene in the different stages of the viral life cycle: viral entry, replication, assembly and budding. Alongside, we describe JUNV tight interplay with the innate immune system. We also review the development of different reverse genetics systems and their use as tools to study JUNV biology and its close teamwork with the host. Elucidating relevant interactions of the virus with the host cell machinery is highly necessary to better understand the mechanistic basis beyond virus multiplication, disease pathogenesis and viral subversion of the immune response. Altogether, this knowledge becomes essential for identifying potential targets for the rational design of novel antiviral treatments to combat JUNV as well as other pathogenic arenaviruses. MDPI 2022-05-24 /pmc/articles/PMC9228484/ /pubmed/35746604 http://dx.doi.org/10.3390/v14061134 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gallo, Giovanna Lucrecia
López, Nora
Loureiro, María Eugenia
The Virus–Host Interplay in Junín Mammarenavirus Infection
title The Virus–Host Interplay in Junín Mammarenavirus Infection
title_full The Virus–Host Interplay in Junín Mammarenavirus Infection
title_fullStr The Virus–Host Interplay in Junín Mammarenavirus Infection
title_full_unstemmed The Virus–Host Interplay in Junín Mammarenavirus Infection
title_short The Virus–Host Interplay in Junín Mammarenavirus Infection
title_sort virus–host interplay in junín mammarenavirus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228484/
https://www.ncbi.nlm.nih.gov/pubmed/35746604
http://dx.doi.org/10.3390/v14061134
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