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The Virus–Host Interplay in Junín Mammarenavirus Infection
Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina. At this moment, there are no effective antiviral therapeutics to battle pathogenic arenaviruses. Cumulative report...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228484/ https://www.ncbi.nlm.nih.gov/pubmed/35746604 http://dx.doi.org/10.3390/v14061134 |
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author | Gallo, Giovanna Lucrecia López, Nora Loureiro, María Eugenia |
author_facet | Gallo, Giovanna Lucrecia López, Nora Loureiro, María Eugenia |
author_sort | Gallo, Giovanna Lucrecia |
collection | PubMed |
description | Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina. At this moment, there are no effective antiviral therapeutics to battle pathogenic arenaviruses. Cumulative reports from recent years have widely provided information on cellular factors playing key roles during JUNV infection. In this review, we summarize research on host molecular determinants that intervene in the different stages of the viral life cycle: viral entry, replication, assembly and budding. Alongside, we describe JUNV tight interplay with the innate immune system. We also review the development of different reverse genetics systems and their use as tools to study JUNV biology and its close teamwork with the host. Elucidating relevant interactions of the virus with the host cell machinery is highly necessary to better understand the mechanistic basis beyond virus multiplication, disease pathogenesis and viral subversion of the immune response. Altogether, this knowledge becomes essential for identifying potential targets for the rational design of novel antiviral treatments to combat JUNV as well as other pathogenic arenaviruses. |
format | Online Article Text |
id | pubmed-9228484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92284842022-06-25 The Virus–Host Interplay in Junín Mammarenavirus Infection Gallo, Giovanna Lucrecia López, Nora Loureiro, María Eugenia Viruses Review Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina. At this moment, there are no effective antiviral therapeutics to battle pathogenic arenaviruses. Cumulative reports from recent years have widely provided information on cellular factors playing key roles during JUNV infection. In this review, we summarize research on host molecular determinants that intervene in the different stages of the viral life cycle: viral entry, replication, assembly and budding. Alongside, we describe JUNV tight interplay with the innate immune system. We also review the development of different reverse genetics systems and their use as tools to study JUNV biology and its close teamwork with the host. Elucidating relevant interactions of the virus with the host cell machinery is highly necessary to better understand the mechanistic basis beyond virus multiplication, disease pathogenesis and viral subversion of the immune response. Altogether, this knowledge becomes essential for identifying potential targets for the rational design of novel antiviral treatments to combat JUNV as well as other pathogenic arenaviruses. MDPI 2022-05-24 /pmc/articles/PMC9228484/ /pubmed/35746604 http://dx.doi.org/10.3390/v14061134 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gallo, Giovanna Lucrecia López, Nora Loureiro, María Eugenia The Virus–Host Interplay in Junín Mammarenavirus Infection |
title | The Virus–Host Interplay in Junín Mammarenavirus Infection |
title_full | The Virus–Host Interplay in Junín Mammarenavirus Infection |
title_fullStr | The Virus–Host Interplay in Junín Mammarenavirus Infection |
title_full_unstemmed | The Virus–Host Interplay in Junín Mammarenavirus Infection |
title_short | The Virus–Host Interplay in Junín Mammarenavirus Infection |
title_sort | virus–host interplay in junín mammarenavirus infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228484/ https://www.ncbi.nlm.nih.gov/pubmed/35746604 http://dx.doi.org/10.3390/v14061134 |
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