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Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania

Background and Objectives: Antibiotics are the most frequently prescribed drugs in hospitals and their prescription is increased during pregnancy and labor. There are limited data about this issue, and the safe use of antibiotics in pregnancy and antibiotic resistance remains a concern. The aim of t...

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Autores principales: Hodoșan, Viviana, Daina, Cristian Marius, Zaha, Dana Carmen, Cotrău, Petru, Vladu, Adriana, Pantiș, Carmen, Dorobanțu, Florica Ramona, Negrău, Marcel, Maghiar, Adriana, Daina, Lucia Georgeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228515/
https://www.ncbi.nlm.nih.gov/pubmed/35744035
http://dx.doi.org/10.3390/medicina58060772
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author Hodoșan, Viviana
Daina, Cristian Marius
Zaha, Dana Carmen
Cotrău, Petru
Vladu, Adriana
Pantiș, Carmen
Dorobanțu, Florica Ramona
Negrău, Marcel
Maghiar, Adriana
Daina, Lucia Georgeta
author_facet Hodoșan, Viviana
Daina, Cristian Marius
Zaha, Dana Carmen
Cotrău, Petru
Vladu, Adriana
Pantiș, Carmen
Dorobanțu, Florica Ramona
Negrău, Marcel
Maghiar, Adriana
Daina, Lucia Georgeta
author_sort Hodoșan, Viviana
collection PubMed
description Background and Objectives: Antibiotics are the most frequently prescribed drugs in hospitals and their prescription is increased during pregnancy and labor. There are limited data about this issue, and the safe use of antibiotics in pregnancy and antibiotic resistance remains a concern. The aim of the study is to evaluate the use of antibiotics among pregnant women attending hospital for five years. Materials and Methods: Antibiotic consumption and treatment information of patients were retrospectively collected from a hospital software program and expressed as defined daily dose (DDD) according to the World Health Organization (WHO) methodology for inpatients between 2017 and 2021. We evaluated antibiotic prescription by name, classes, and Food and Drug Administration (FDA) categories. Results: Antibiotic consumption shows a decreasing trend between 2017 and 2019, but an increasing one between 2020 and 2021. Ceftriaxone was the most prescribed antibiotic in each year, followed by cefixime, amoxicillin, metronidazole, cefuroxime, ampicillin, and ciprofloxacin. We noticed that first- and fourth-generation cephalosporins were not prescribed to these patients. A very small percentage of women in this study received antibiotics such as aminoglycosides; fluoroquinolones were generally contraindicated in the perinatal period. A large percentage of prescriptions were antibiotics classified as category B by the FDA. The most common infections that occurred in the perinatal period were those of the kidney and urinary tract in a higher number than in other studies. Conclusions: Our study shows that many classes of antibiotics used in perinatal women belong to category B antibiotics, the most prescribed being cephalosporins. Because of insufficient safety evidence and the potential for teratogenic effects on the fetus, restricted use among the category C and D antibiotic classes was seen and anticipated. Improving maternal health requires the involvement of healthcare experts in risk assessment and evaluation of existing data for appropriate antibiotic selection, dose, duration of medication, and monitoring.
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spelling pubmed-92285152022-06-25 Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania Hodoșan, Viviana Daina, Cristian Marius Zaha, Dana Carmen Cotrău, Petru Vladu, Adriana Pantiș, Carmen Dorobanțu, Florica Ramona Negrău, Marcel Maghiar, Adriana Daina, Lucia Georgeta Medicina (Kaunas) Article Background and Objectives: Antibiotics are the most frequently prescribed drugs in hospitals and their prescription is increased during pregnancy and labor. There are limited data about this issue, and the safe use of antibiotics in pregnancy and antibiotic resistance remains a concern. The aim of the study is to evaluate the use of antibiotics among pregnant women attending hospital for five years. Materials and Methods: Antibiotic consumption and treatment information of patients were retrospectively collected from a hospital software program and expressed as defined daily dose (DDD) according to the World Health Organization (WHO) methodology for inpatients between 2017 and 2021. We evaluated antibiotic prescription by name, classes, and Food and Drug Administration (FDA) categories. Results: Antibiotic consumption shows a decreasing trend between 2017 and 2019, but an increasing one between 2020 and 2021. Ceftriaxone was the most prescribed antibiotic in each year, followed by cefixime, amoxicillin, metronidazole, cefuroxime, ampicillin, and ciprofloxacin. We noticed that first- and fourth-generation cephalosporins were not prescribed to these patients. A very small percentage of women in this study received antibiotics such as aminoglycosides; fluoroquinolones were generally contraindicated in the perinatal period. A large percentage of prescriptions were antibiotics classified as category B by the FDA. The most common infections that occurred in the perinatal period were those of the kidney and urinary tract in a higher number than in other studies. Conclusions: Our study shows that many classes of antibiotics used in perinatal women belong to category B antibiotics, the most prescribed being cephalosporins. Because of insufficient safety evidence and the potential for teratogenic effects on the fetus, restricted use among the category C and D antibiotic classes was seen and anticipated. Improving maternal health requires the involvement of healthcare experts in risk assessment and evaluation of existing data for appropriate antibiotic selection, dose, duration of medication, and monitoring. MDPI 2022-06-07 /pmc/articles/PMC9228515/ /pubmed/35744035 http://dx.doi.org/10.3390/medicina58060772 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hodoșan, Viviana
Daina, Cristian Marius
Zaha, Dana Carmen
Cotrău, Petru
Vladu, Adriana
Pantiș, Carmen
Dorobanțu, Florica Ramona
Negrău, Marcel
Maghiar, Adriana
Daina, Lucia Georgeta
Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania
title Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania
title_full Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania
title_fullStr Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania
title_full_unstemmed Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania
title_short Pattern of Antibiotic Use in the Perinatal Period in a Public University Hospital in Romania
title_sort pattern of antibiotic use in the perinatal period in a public university hospital in romania
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228515/
https://www.ncbi.nlm.nih.gov/pubmed/35744035
http://dx.doi.org/10.3390/medicina58060772
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