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Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium

Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food freque...

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Autores principales: Collatuzzo, Giulia, Teglia, Federica, Pelucchi, Claudio, Negri, Eva, Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, López-Carrillo, Lizbeth, Lunet, Nuno, Morais, Samantha, Aragonés, Nuria, Moreno, Victor, Vioque, Jesus, Garcia de la Hera, Manoli, Ward, Mary H., Malekzadeh, Reza, Pakseresht, Mohammadreza, Hernández-Ramírez, Raúl Ulises, López-Cervantes, Malaquias, Bonzi, Rossella, Dalmartello, Michela, Tsugane, Shoichiro, Hidaka, Akihisa, Camargo, M. Constanza, Curado, Maria Paula, Zhang, Zuo-Feng, Zubair, Nadia, La Vecchia, Carlo, Shah, Shailja, Boffetta, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228527/
https://www.ncbi.nlm.nih.gov/pubmed/35745285
http://dx.doi.org/10.3390/nu14122555
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author Collatuzzo, Giulia
Teglia, Federica
Pelucchi, Claudio
Negri, Eva
Rabkin, Charles S.
Liao, Linda M.
Sinha, Rashmi
López-Carrillo, Lizbeth
Lunet, Nuno
Morais, Samantha
Aragonés, Nuria
Moreno, Victor
Vioque, Jesus
Garcia de la Hera, Manoli
Ward, Mary H.
Malekzadeh, Reza
Pakseresht, Mohammadreza
Hernández-Ramírez, Raúl Ulises
López-Cervantes, Malaquias
Bonzi, Rossella
Dalmartello, Michela
Tsugane, Shoichiro
Hidaka, Akihisa
Camargo, M. Constanza
Curado, Maria Paula
Zhang, Zuo-Feng
Zubair, Nadia
La Vecchia, Carlo
Shah, Shailja
Boffetta, Paolo
author_facet Collatuzzo, Giulia
Teglia, Federica
Pelucchi, Claudio
Negri, Eva
Rabkin, Charles S.
Liao, Linda M.
Sinha, Rashmi
López-Carrillo, Lizbeth
Lunet, Nuno
Morais, Samantha
Aragonés, Nuria
Moreno, Victor
Vioque, Jesus
Garcia de la Hera, Manoli
Ward, Mary H.
Malekzadeh, Reza
Pakseresht, Mohammadreza
Hernández-Ramírez, Raúl Ulises
López-Cervantes, Malaquias
Bonzi, Rossella
Dalmartello, Michela
Tsugane, Shoichiro
Hidaka, Akihisa
Camargo, M. Constanza
Curado, Maria Paula
Zhang, Zuo-Feng
Zubair, Nadia
La Vecchia, Carlo
Shah, Shailja
Boffetta, Paolo
author_sort Collatuzzo, Giulia
collection PubMed
description Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83–0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77–0.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81–0.94), and for diffuse (OR = 0.79, 95% CI = 0.69–0.89) and intestinal type (OR = 0.88, 95% CI = 0.79–0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis.
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spelling pubmed-92285272022-06-25 Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium Collatuzzo, Giulia Teglia, Federica Pelucchi, Claudio Negri, Eva Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Aragonés, Nuria Moreno, Victor Vioque, Jesus Garcia de la Hera, Manoli Ward, Mary H. Malekzadeh, Reza Pakseresht, Mohammadreza Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Bonzi, Rossella Dalmartello, Michela Tsugane, Shoichiro Hidaka, Akihisa Camargo, M. Constanza Curado, Maria Paula Zhang, Zuo-Feng Zubair, Nadia La Vecchia, Carlo Shah, Shailja Boffetta, Paolo Nutrients Article Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83–0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77–0.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81–0.94), and for diffuse (OR = 0.79, 95% CI = 0.69–0.89) and intestinal type (OR = 0.88, 95% CI = 0.79–0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis. MDPI 2022-06-20 /pmc/articles/PMC9228527/ /pubmed/35745285 http://dx.doi.org/10.3390/nu14122555 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Collatuzzo, Giulia
Teglia, Federica
Pelucchi, Claudio
Negri, Eva
Rabkin, Charles S.
Liao, Linda M.
Sinha, Rashmi
López-Carrillo, Lizbeth
Lunet, Nuno
Morais, Samantha
Aragonés, Nuria
Moreno, Victor
Vioque, Jesus
Garcia de la Hera, Manoli
Ward, Mary H.
Malekzadeh, Reza
Pakseresht, Mohammadreza
Hernández-Ramírez, Raúl Ulises
López-Cervantes, Malaquias
Bonzi, Rossella
Dalmartello, Michela
Tsugane, Shoichiro
Hidaka, Akihisa
Camargo, M. Constanza
Curado, Maria Paula
Zhang, Zuo-Feng
Zubair, Nadia
La Vecchia, Carlo
Shah, Shailja
Boffetta, Paolo
Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium
title Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium
title_full Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium
title_fullStr Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium
title_full_unstemmed Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium
title_short Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium
title_sort inverse association between dietary iron intake and gastric cancer: a pooled analysis of case-control studies of the stop consortium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228527/
https://www.ncbi.nlm.nih.gov/pubmed/35745285
http://dx.doi.org/10.3390/nu14122555
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