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Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium
Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food freque...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228527/ https://www.ncbi.nlm.nih.gov/pubmed/35745285 http://dx.doi.org/10.3390/nu14122555 |
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author | Collatuzzo, Giulia Teglia, Federica Pelucchi, Claudio Negri, Eva Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Aragonés, Nuria Moreno, Victor Vioque, Jesus Garcia de la Hera, Manoli Ward, Mary H. Malekzadeh, Reza Pakseresht, Mohammadreza Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Bonzi, Rossella Dalmartello, Michela Tsugane, Shoichiro Hidaka, Akihisa Camargo, M. Constanza Curado, Maria Paula Zhang, Zuo-Feng Zubair, Nadia La Vecchia, Carlo Shah, Shailja Boffetta, Paolo |
author_facet | Collatuzzo, Giulia Teglia, Federica Pelucchi, Claudio Negri, Eva Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Aragonés, Nuria Moreno, Victor Vioque, Jesus Garcia de la Hera, Manoli Ward, Mary H. Malekzadeh, Reza Pakseresht, Mohammadreza Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Bonzi, Rossella Dalmartello, Michela Tsugane, Shoichiro Hidaka, Akihisa Camargo, M. Constanza Curado, Maria Paula Zhang, Zuo-Feng Zubair, Nadia La Vecchia, Carlo Shah, Shailja Boffetta, Paolo |
author_sort | Collatuzzo, Giulia |
collection | PubMed |
description | Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83–0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77–0.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81–0.94), and for diffuse (OR = 0.79, 95% CI = 0.69–0.89) and intestinal type (OR = 0.88, 95% CI = 0.79–0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis. |
format | Online Article Text |
id | pubmed-9228527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92285272022-06-25 Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium Collatuzzo, Giulia Teglia, Federica Pelucchi, Claudio Negri, Eva Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Aragonés, Nuria Moreno, Victor Vioque, Jesus Garcia de la Hera, Manoli Ward, Mary H. Malekzadeh, Reza Pakseresht, Mohammadreza Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Bonzi, Rossella Dalmartello, Michela Tsugane, Shoichiro Hidaka, Akihisa Camargo, M. Constanza Curado, Maria Paula Zhang, Zuo-Feng Zubair, Nadia La Vecchia, Carlo Shah, Shailja Boffetta, Paolo Nutrients Article Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83–0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77–0.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81–0.94), and for diffuse (OR = 0.79, 95% CI = 0.69–0.89) and intestinal type (OR = 0.88, 95% CI = 0.79–0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis. MDPI 2022-06-20 /pmc/articles/PMC9228527/ /pubmed/35745285 http://dx.doi.org/10.3390/nu14122555 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Collatuzzo, Giulia Teglia, Federica Pelucchi, Claudio Negri, Eva Rabkin, Charles S. Liao, Linda M. Sinha, Rashmi López-Carrillo, Lizbeth Lunet, Nuno Morais, Samantha Aragonés, Nuria Moreno, Victor Vioque, Jesus Garcia de la Hera, Manoli Ward, Mary H. Malekzadeh, Reza Pakseresht, Mohammadreza Hernández-Ramírez, Raúl Ulises López-Cervantes, Malaquias Bonzi, Rossella Dalmartello, Michela Tsugane, Shoichiro Hidaka, Akihisa Camargo, M. Constanza Curado, Maria Paula Zhang, Zuo-Feng Zubair, Nadia La Vecchia, Carlo Shah, Shailja Boffetta, Paolo Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium |
title | Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium |
title_full | Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium |
title_fullStr | Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium |
title_full_unstemmed | Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium |
title_short | Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium |
title_sort | inverse association between dietary iron intake and gastric cancer: a pooled analysis of case-control studies of the stop consortium |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228527/ https://www.ncbi.nlm.nih.gov/pubmed/35745285 http://dx.doi.org/10.3390/nu14122555 |
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