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Fasting Enhances the Acute Toxicity of Acrylonitrile in Mice via Induction of CYP2E1

Cytochrome P450 2E1 (CYP2E1) plays an essential role in the susceptibility to acute acrylonitrile (AN)-induced toxicity. Here, we investigated the toxicity and mechanism of AN in fasting mice and potential underlying mechanisms. Convulsions, loss of righting reflex, and death 4 h after AN treatment...

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Detalles Bibliográficos
Autores principales:	Wang, Suhua, Xing, Guangwei, Li, Fang, Yang, Bobo, Zhang, Yu, Aschner, Michael, Lu, Rongzhu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228628/ https://www.ncbi.nlm.nih.gov/pubmed/35736945 http://dx.doi.org/10.3390/toxics10060337

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