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Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner

Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4, are produced from nonstructural polyprotein...

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Detalles Bibliográficos
Autores principales: Cherkashchenko, Liubov, Rausalu, Kai, Basu, Sanjay, Alphey, Luke, Merits, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228716/
https://www.ncbi.nlm.nih.gov/pubmed/35746799
http://dx.doi.org/10.3390/v14061327