Cargando…
Expression of Alphavirus Nonstructural Protein 2 (nsP2) in Mosquito Cells Inhibits Viral RNA Replication in Both a Protease Activity-Dependent and -Independent Manner
Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4, are produced from nonstructural polyprotein...
Autores principales: | Cherkashchenko, Liubov, Rausalu, Kai, Basu, Sanjay, Alphey, Luke, Merits, Andres |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228716/ https://www.ncbi.nlm.nih.gov/pubmed/35746799 http://dx.doi.org/10.3390/v14061327 |
Ejemplares similares
-
nsP4 Is a Major Determinant of Alphavirus Replicase Activity and Template Selectivity
por: Lello, Laura Sandra, et al.
Publicado: (2021) -
1,3-Thiazolbenzamide Derivatives as Chikungunya Virus
nsP2 Protease Inhibitors
por: Ivanova, Larisa, et al.
Publicado: (2021) -
Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold
por: Tan, Yaw Bia, et al.
Publicado: (2022) -
Alphavirus Nonstructural Proteases and Their Inhibitors
por: Bissoyi, Akalabya, et al.
Publicado: (2017) -
Full length and protease domain activity of chikungunya virus nsP2 differ from other alphavirus nsP2 proteases in recognition of small peptide substrates
por: Saisawang, Chonticha, et al.
Publicado: (2015)