Cargando…

Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns

Fibers and yarns are part of everyday life. So far, fibers that are also used pharmaceutically have mainly been produced by electrospinning. The common use of spinning oils and the excipients they contain, in connection with production by melt extrusion, poses a regulatory challenge for pharmaceutic...

Descripción completa

Detalles Bibliográficos
Autores principales: Rosenbaum, Christoph, Großmann, Linus, Neumann, Ellen, Jungfleisch, Petra, Türeli, Emre, Weitschies, Werner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228848/
https://www.ncbi.nlm.nih.gov/pubmed/35745801
http://dx.doi.org/10.3390/pharmaceutics14061229
_version_ 1784734583099490304
author Rosenbaum, Christoph
Großmann, Linus
Neumann, Ellen
Jungfleisch, Petra
Türeli, Emre
Weitschies, Werner
author_facet Rosenbaum, Christoph
Großmann, Linus
Neumann, Ellen
Jungfleisch, Petra
Türeli, Emre
Weitschies, Werner
author_sort Rosenbaum, Christoph
collection PubMed
description Fibers and yarns are part of everyday life. So far, fibers that are also used pharmaceutically have mainly been produced by electrospinning. The common use of spinning oils and the excipients they contain, in connection with production by melt extrusion, poses a regulatory challenge for pharmaceutically usable fibers. In this publication, a newly developed small-scale direct-spinning melt extrusion system is described, and the pharmaceutically useful polyvinyl filaments produced with it are characterized. The major parts of the system were newly developed or extensively modified and manufactured cost-effectively within a short time using rapid prototyping (3D printing) from various materials. For example, a stainless-steel spinneret was developed in a splice design for a table-top melt extrusion system that can be used in the pharmaceutical industry. The direct processing of the extruded fibers was made possible by a spinning system developed called Spinning-Rosi, which operates continuously and directly in the extrusion process and eliminates the need for spinning oils. In order to prevent instabilities in the product, further modifications were also made to the process, such as a the moisture encapsulation of the melt extrusion line at certain points, which resulted in a bubble-free extrudate with high tensile strength, even in a melt extrusion line without built-in venting.
format Online
Article
Text
id pubmed-9228848
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92288482022-06-25 Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns Rosenbaum, Christoph Großmann, Linus Neumann, Ellen Jungfleisch, Petra Türeli, Emre Weitschies, Werner Pharmaceutics Article Fibers and yarns are part of everyday life. So far, fibers that are also used pharmaceutically have mainly been produced by electrospinning. The common use of spinning oils and the excipients they contain, in connection with production by melt extrusion, poses a regulatory challenge for pharmaceutically usable fibers. In this publication, a newly developed small-scale direct-spinning melt extrusion system is described, and the pharmaceutically useful polyvinyl filaments produced with it are characterized. The major parts of the system were newly developed or extensively modified and manufactured cost-effectively within a short time using rapid prototyping (3D printing) from various materials. For example, a stainless-steel spinneret was developed in a splice design for a table-top melt extrusion system that can be used in the pharmaceutical industry. The direct processing of the extruded fibers was made possible by a spinning system developed called Spinning-Rosi, which operates continuously and directly in the extrusion process and eliminates the need for spinning oils. In order to prevent instabilities in the product, further modifications were also made to the process, such as a the moisture encapsulation of the melt extrusion line at certain points, which resulted in a bubble-free extrudate with high tensile strength, even in a melt extrusion line without built-in venting. MDPI 2022-06-10 /pmc/articles/PMC9228848/ /pubmed/35745801 http://dx.doi.org/10.3390/pharmaceutics14061229 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rosenbaum, Christoph
Großmann, Linus
Neumann, Ellen
Jungfleisch, Petra
Türeli, Emre
Weitschies, Werner
Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns
title Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns
title_full Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns
title_fullStr Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns
title_full_unstemmed Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns
title_short Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns
title_sort development of a hot-melt-extrusion-based spinning process to produce pharmaceutical fibers and yarns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228848/
https://www.ncbi.nlm.nih.gov/pubmed/35745801
http://dx.doi.org/10.3390/pharmaceutics14061229
work_keys_str_mv AT rosenbaumchristoph developmentofahotmeltextrusionbasedspinningprocesstoproducepharmaceuticalfibersandyarns
AT großmannlinus developmentofahotmeltextrusionbasedspinningprocesstoproducepharmaceuticalfibersandyarns
AT neumannellen developmentofahotmeltextrusionbasedspinningprocesstoproducepharmaceuticalfibersandyarns
AT jungfleischpetra developmentofahotmeltextrusionbasedspinningprocesstoproducepharmaceuticalfibersandyarns
AT tureliemre developmentofahotmeltextrusionbasedspinningprocesstoproducepharmaceuticalfibersandyarns
AT weitschieswerner developmentofahotmeltextrusionbasedspinningprocesstoproducepharmaceuticalfibersandyarns