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Peptidomimetic Lipid-Nanoparticle-Mediated Knockdown of TLR4 in CNS Protects against Cerebral Ischemia/Reperfusion Injury in Mice

Ischemic stroke activates toll-like receptor 4 (TLR4) signaling, resulting in proinflammatory polarization of microglia and secondary neuronal damage. Herein, we report a novel lipid-nanoparticle (LNP)-mediated knockdown of TLR4 in microglia and amelioration of neuroinflammation in a mouse model of...

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Detalles Bibliográficos
Autores principales:	Ganbold, Tsogzolmaa, Bao, Qingming, Xiao, Hai, Zurgaanjin, Dolgorsuren, Liu, Caifeng, Han, Shuqin, Hasi, Agula, Baigude, Huricha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228890/ https://www.ncbi.nlm.nih.gov/pubmed/35745411 http://dx.doi.org/10.3390/nano12122072

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