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The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad
When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike prot...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228905/ https://www.ncbi.nlm.nih.gov/pubmed/35746456 http://dx.doi.org/10.3390/vaccines10060848 |
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author | Popescu, Daniela-Eugenia Cîtu, Cosmin Jura, Ana Maria Cristina Lungu, Nicoleta Navolan, Dan Craina, Marius Semenescu, Alin Gorun, Florin Jura, Mihai-Andrei Belengeanu, Valerica Boia, Marioara |
author_facet | Popescu, Daniela-Eugenia Cîtu, Cosmin Jura, Ana Maria Cristina Lungu, Nicoleta Navolan, Dan Craina, Marius Semenescu, Alin Gorun, Florin Jura, Mihai-Andrei Belengeanu, Valerica Boia, Marioara |
author_sort | Popescu, Daniela-Eugenia |
collection | PubMed |
description | When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, t(90) = 8.91, p < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care. |
format | Online Article Text |
id | pubmed-9228905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92289052022-06-25 The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad Popescu, Daniela-Eugenia Cîtu, Cosmin Jura, Ana Maria Cristina Lungu, Nicoleta Navolan, Dan Craina, Marius Semenescu, Alin Gorun, Florin Jura, Mihai-Andrei Belengeanu, Valerica Boia, Marioara Vaccines (Basel) Article When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, t(90) = 8.91, p < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care. MDPI 2022-05-26 /pmc/articles/PMC9228905/ /pubmed/35746456 http://dx.doi.org/10.3390/vaccines10060848 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Popescu, Daniela-Eugenia Cîtu, Cosmin Jura, Ana Maria Cristina Lungu, Nicoleta Navolan, Dan Craina, Marius Semenescu, Alin Gorun, Florin Jura, Mihai-Andrei Belengeanu, Valerica Boia, Marioara The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
title | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
title_full | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
title_fullStr | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
title_full_unstemmed | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
title_short | The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad |
title_sort | benefits of vaccination against sars-cov-2 during pregnancy in favor of the mother/newborn dyad |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228905/ https://www.ncbi.nlm.nih.gov/pubmed/35746456 http://dx.doi.org/10.3390/vaccines10060848 |
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