Cargando…

The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad

When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike prot...

Descripción completa

Detalles Bibliográficos
Autores principales: Popescu, Daniela-Eugenia, Cîtu, Cosmin, Jura, Ana Maria Cristina, Lungu, Nicoleta, Navolan, Dan, Craina, Marius, Semenescu, Alin, Gorun, Florin, Jura, Mihai-Andrei, Belengeanu, Valerica, Boia, Marioara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228905/
https://www.ncbi.nlm.nih.gov/pubmed/35746456
http://dx.doi.org/10.3390/vaccines10060848
_version_ 1784734597989269504
author Popescu, Daniela-Eugenia
Cîtu, Cosmin
Jura, Ana Maria Cristina
Lungu, Nicoleta
Navolan, Dan
Craina, Marius
Semenescu, Alin
Gorun, Florin
Jura, Mihai-Andrei
Belengeanu, Valerica
Boia, Marioara
author_facet Popescu, Daniela-Eugenia
Cîtu, Cosmin
Jura, Ana Maria Cristina
Lungu, Nicoleta
Navolan, Dan
Craina, Marius
Semenescu, Alin
Gorun, Florin
Jura, Mihai-Andrei
Belengeanu, Valerica
Boia, Marioara
author_sort Popescu, Daniela-Eugenia
collection PubMed
description When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, t(90) = 8.91, p < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care.
format Online
Article
Text
id pubmed-9228905
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-92289052022-06-25 The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad Popescu, Daniela-Eugenia Cîtu, Cosmin Jura, Ana Maria Cristina Lungu, Nicoleta Navolan, Dan Craina, Marius Semenescu, Alin Gorun, Florin Jura, Mihai-Andrei Belengeanu, Valerica Boia, Marioara Vaccines (Basel) Article When the first vaccines against SARS-CoV-2 emerged, pregnant women were excluded from clinical trials, so vaccine recommendations were initially adjourned, with late initiation for this populational category. The present study aims to quantify the serum and breastmilk values of SARS-CoV-2 spike protein antibodies in both the mother and her newborn after complete vaccination during pregnancy. Ninety-one vaccinated patients were included, some of whom presented COVID-19 infection during pregnancy. In the delivery room, venous blood was collected from the mother and umbilical cord blood from her offspring. All samples were processed using the ECLIA (electrochemiluminescence) method. Breastmilk was collected and tested during the third postnatal day. The highest maternal serum values were 19,523 U/mL (detection limit > 0.8 U/mL) and in breastmilk, 206.7 U/mL. Every single newborn had antibody values higher than 0, with a mean serum value (M = 5288.37, SD = 5661.49) significantly higher than 0, t(90) = 8.91, p < 0.001. Consequently, this study intents to emphasize the importance of vaccination against SARS-CoV-2 during pregnancy. This double kind of neonatal protection, attained by placental and breastmilk transfer, can be accomplished by encouraging vaccination, breastfeeding, bonding, and providing maternal empowerment to participate in her infant’s care. MDPI 2022-05-26 /pmc/articles/PMC9228905/ /pubmed/35746456 http://dx.doi.org/10.3390/vaccines10060848 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Popescu, Daniela-Eugenia
Cîtu, Cosmin
Jura, Ana Maria Cristina
Lungu, Nicoleta
Navolan, Dan
Craina, Marius
Semenescu, Alin
Gorun, Florin
Jura, Mihai-Andrei
Belengeanu, Valerica
Boia, Marioara
The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad
title The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad
title_full The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad
title_fullStr The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad
title_full_unstemmed The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad
title_short The Benefits of Vaccination against SARS-CoV-2 during Pregnancy in Favor of the Mother/Newborn Dyad
title_sort benefits of vaccination against sars-cov-2 during pregnancy in favor of the mother/newborn dyad
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228905/
https://www.ncbi.nlm.nih.gov/pubmed/35746456
http://dx.doi.org/10.3390/vaccines10060848
work_keys_str_mv AT popescudanielaeugenia thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT citucosmin thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT juraanamariacristina thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT lungunicoleta thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT navolandan thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT crainamarius thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT semenescualin thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT gorunflorin thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT juramihaiandrei thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT belengeanuvalerica thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT boiamarioara thebenefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT popescudanielaeugenia benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT citucosmin benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT juraanamariacristina benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT lungunicoleta benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT navolandan benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT crainamarius benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT semenescualin benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT gorunflorin benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT juramihaiandrei benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT belengeanuvalerica benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad
AT boiamarioara benefitsofvaccinationagainstsarscov2duringpregnancyinfavorofthemothernewborndyad