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Faecal Microbiota Transplantation and Chronic Kidney Disease
Faecal microbiota transplantation (FMT) has attracted increasing attention as an intervention in many clinical conditions, including autoimmune, enteroendocrine, gastroenterological, and neurological diseases. For years, FMT has been an effective second-line treatment for Clostridium difficile infec...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228952/ https://www.ncbi.nlm.nih.gov/pubmed/35745257 http://dx.doi.org/10.3390/nu14122528 |
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author | Bian, Ji Liebert, Ann Bicknell, Brian Chen, Xin-Ming Huang, Chunling Pollock, Carol A. |
author_facet | Bian, Ji Liebert, Ann Bicknell, Brian Chen, Xin-Ming Huang, Chunling Pollock, Carol A. |
author_sort | Bian, Ji |
collection | PubMed |
description | Faecal microbiota transplantation (FMT) has attracted increasing attention as an intervention in many clinical conditions, including autoimmune, enteroendocrine, gastroenterological, and neurological diseases. For years, FMT has been an effective second-line treatment for Clostridium difficile infection (CDI) with beneficial outcomes. FMT is also promising in improving bowel diseases, such as ulcerative colitis (UC). Pre-clinical and clinical studies suggest that this microbiota-based intervention may influence the development and progression of chronic kidney disease (CKD) via modifying a dysregulated gut–kidney axis. Despite the high morbidity and mortality due to CKD, there are limited options for treatment until end-stage kidney disease occurs, which results in death, dialysis, or kidney transplantation. This imposes a significant financial and health burden on the individual, their families and careers, and the health system. Recent studies have suggested that strategies to reverse gut dysbiosis using FMT are a promising therapy in CKD. This review summarises the preclinical and clinical evidence and postulates the potential therapeutic effect of FMT in the management of CKD. |
format | Online Article Text |
id | pubmed-9228952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92289522022-06-25 Faecal Microbiota Transplantation and Chronic Kidney Disease Bian, Ji Liebert, Ann Bicknell, Brian Chen, Xin-Ming Huang, Chunling Pollock, Carol A. Nutrients Review Faecal microbiota transplantation (FMT) has attracted increasing attention as an intervention in many clinical conditions, including autoimmune, enteroendocrine, gastroenterological, and neurological diseases. For years, FMT has been an effective second-line treatment for Clostridium difficile infection (CDI) with beneficial outcomes. FMT is also promising in improving bowel diseases, such as ulcerative colitis (UC). Pre-clinical and clinical studies suggest that this microbiota-based intervention may influence the development and progression of chronic kidney disease (CKD) via modifying a dysregulated gut–kidney axis. Despite the high morbidity and mortality due to CKD, there are limited options for treatment until end-stage kidney disease occurs, which results in death, dialysis, or kidney transplantation. This imposes a significant financial and health burden on the individual, their families and careers, and the health system. Recent studies have suggested that strategies to reverse gut dysbiosis using FMT are a promising therapy in CKD. This review summarises the preclinical and clinical evidence and postulates the potential therapeutic effect of FMT in the management of CKD. MDPI 2022-06-17 /pmc/articles/PMC9228952/ /pubmed/35745257 http://dx.doi.org/10.3390/nu14122528 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bian, Ji Liebert, Ann Bicknell, Brian Chen, Xin-Ming Huang, Chunling Pollock, Carol A. Faecal Microbiota Transplantation and Chronic Kidney Disease |
title | Faecal Microbiota Transplantation and Chronic Kidney Disease |
title_full | Faecal Microbiota Transplantation and Chronic Kidney Disease |
title_fullStr | Faecal Microbiota Transplantation and Chronic Kidney Disease |
title_full_unstemmed | Faecal Microbiota Transplantation and Chronic Kidney Disease |
title_short | Faecal Microbiota Transplantation and Chronic Kidney Disease |
title_sort | faecal microbiota transplantation and chronic kidney disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228952/ https://www.ncbi.nlm.nih.gov/pubmed/35745257 http://dx.doi.org/10.3390/nu14122528 |
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