Cargando…
A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model
Without sufficient herd immunity through either vaccination or natural infection, the coronavirus disease 2019 pandemic is unlikely to be controlled. Waning immunity with the currently approved vaccines suggests the need to evaluate vaccines causing the induction of long-term responses. Here, we rep...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229041/ https://www.ncbi.nlm.nih.gov/pubmed/35746597 http://dx.doi.org/10.3390/v14061126 |
_version_ | 1784734636045238272 |
---|---|
author | Kurup, Drishya Wirblich, Christoph Zabihi Diba, Leila Lambert, Rachael Watson, Megan Shaikh, Noor Ramage, Holly Solomides, Charalambos Schnell, Matthias J. |
author_facet | Kurup, Drishya Wirblich, Christoph Zabihi Diba, Leila Lambert, Rachael Watson, Megan Shaikh, Noor Ramage, Holly Solomides, Charalambos Schnell, Matthias J. |
author_sort | Kurup, Drishya |
collection | PubMed |
description | Without sufficient herd immunity through either vaccination or natural infection, the coronavirus disease 2019 pandemic is unlikely to be controlled. Waning immunity with the currently approved vaccines suggests the need to evaluate vaccines causing the induction of long-term responses. Here, we report the immunogenicity and efficacy of our adjuvanted single-dose Rabies-vectored SARS-CoV-2 S1 vaccine, CORAVAX, in hamsters. CORAVAX induces high SARS-CoV-2 S1-specific and virus-neutralizing antibodies (VNAs) that prevent weight loss, viral loads, disease, lung inflammation, and the cytokine storm in hamsters. We also observed high Rabies VNA titers. In summary, CORAVAX is a promising dual-antigen vaccine candidate for clinical evaluation against SARS-CoV-2 and Rabies virus. |
format | Online Article Text |
id | pubmed-9229041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92290412022-06-25 A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model Kurup, Drishya Wirblich, Christoph Zabihi Diba, Leila Lambert, Rachael Watson, Megan Shaikh, Noor Ramage, Holly Solomides, Charalambos Schnell, Matthias J. Viruses Article Without sufficient herd immunity through either vaccination or natural infection, the coronavirus disease 2019 pandemic is unlikely to be controlled. Waning immunity with the currently approved vaccines suggests the need to evaluate vaccines causing the induction of long-term responses. Here, we report the immunogenicity and efficacy of our adjuvanted single-dose Rabies-vectored SARS-CoV-2 S1 vaccine, CORAVAX, in hamsters. CORAVAX induces high SARS-CoV-2 S1-specific and virus-neutralizing antibodies (VNAs) that prevent weight loss, viral loads, disease, lung inflammation, and the cytokine storm in hamsters. We also observed high Rabies VNA titers. In summary, CORAVAX is a promising dual-antigen vaccine candidate for clinical evaluation against SARS-CoV-2 and Rabies virus. MDPI 2022-05-24 /pmc/articles/PMC9229041/ /pubmed/35746597 http://dx.doi.org/10.3390/v14061126 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kurup, Drishya Wirblich, Christoph Zabihi Diba, Leila Lambert, Rachael Watson, Megan Shaikh, Noor Ramage, Holly Solomides, Charalambos Schnell, Matthias J. A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model |
title | A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model |
title_full | A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model |
title_fullStr | A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model |
title_full_unstemmed | A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model |
title_short | A Single Dose of the Deactivated Rabies-Virus Vectored COVID-19 Vaccine, CORAVAX, Is Highly Efficacious and Alleviates Lung Inflammation in the Hamster Model |
title_sort | single dose of the deactivated rabies-virus vectored covid-19 vaccine, coravax, is highly efficacious and alleviates lung inflammation in the hamster model |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229041/ https://www.ncbi.nlm.nih.gov/pubmed/35746597 http://dx.doi.org/10.3390/v14061126 |
work_keys_str_mv | AT kurupdrishya asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT wirblichchristoph asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT zabihidibaleila asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT lambertrachael asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT watsonmegan asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT shaikhnoor asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT ramageholly asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT solomidescharalambos asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT schnellmatthiasj asingledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT kurupdrishya singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT wirblichchristoph singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT zabihidibaleila singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT lambertrachael singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT watsonmegan singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT shaikhnoor singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT ramageholly singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT solomidescharalambos singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel AT schnellmatthiasj singledoseofthedeactivatedrabiesvirusvectoredcovid19vaccinecoravaxishighlyefficaciousandalleviateslunginflammationinthehamstermodel |