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Brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients
BACKGROUND: The purpose of the study was to assess the ultrasound measurements of the brachial artery flow-mediated dilation (FMD) and carotid artery intima-media thickness (IMT) and their relationship in glaucoma patients. METHODS: Thirty-seven patients with glaucoma and thirty-one healthy controls...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229099/ https://www.ncbi.nlm.nih.gov/pubmed/35739540 http://dx.doi.org/10.1186/s12886-022-02498-5 |
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author | Bojic, Lovro Rogosic, Veljko Markovic, Domagoj Rogosic, Lucija Vanjaka Glavas, Duska |
author_facet | Bojic, Lovro Rogosic, Veljko Markovic, Domagoj Rogosic, Lucija Vanjaka Glavas, Duska |
author_sort | Bojic, Lovro |
collection | PubMed |
description | BACKGROUND: The purpose of the study was to assess the ultrasound measurements of the brachial artery flow-mediated dilation (FMD) and carotid artery intima-media thickness (IMT) and their relationship in glaucoma patients. METHODS: Thirty-seven patients with glaucoma and thirty-one healthy controls were included in the study. All glaucoma patients and controls underwent ultrasound measurement of FMD of the brachial artery and ultrasound measurement of IMT of the carotid artery. RESULTS: The mean values of brachial FMD were significantly lower among the glaucoma compared with controls (16.4 ± 10.6% vs 20.3 ± 8.5%, p = 0.034). No significant difference was found in carotid IMT (1.2 ± 0.4 vs. 1.1 ± 0.4, p = 0.3), and brachial artery diameter at rest (4.7 ± 0.6 vs. 4.9 ± 0.3, p = 0.2) between the glaucoma patients and controls. The significant difference in brachial artery diameter in hyperemia between the glaucoma patients and controls (5.5 ± 0.6 vs. 5.9 ± 0.4 p = 0.002) was found. A negative correlation among brachial FMD and carotid IMT as well as among brachial FMD and brachial artery diameter at rest was found. CONCLUSIONS: Impaired brachial FMD indicates presence of systemic vascular endothelial dysfunction in glaucoma; glaucoma patients with lower values of the brachial FMD are at increased risk of having thickened carotid IMT. |
format | Online Article Text |
id | pubmed-9229099 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92290992022-06-25 Brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients Bojic, Lovro Rogosic, Veljko Markovic, Domagoj Rogosic, Lucija Vanjaka Glavas, Duska BMC Ophthalmol Research BACKGROUND: The purpose of the study was to assess the ultrasound measurements of the brachial artery flow-mediated dilation (FMD) and carotid artery intima-media thickness (IMT) and their relationship in glaucoma patients. METHODS: Thirty-seven patients with glaucoma and thirty-one healthy controls were included in the study. All glaucoma patients and controls underwent ultrasound measurement of FMD of the brachial artery and ultrasound measurement of IMT of the carotid artery. RESULTS: The mean values of brachial FMD were significantly lower among the glaucoma compared with controls (16.4 ± 10.6% vs 20.3 ± 8.5%, p = 0.034). No significant difference was found in carotid IMT (1.2 ± 0.4 vs. 1.1 ± 0.4, p = 0.3), and brachial artery diameter at rest (4.7 ± 0.6 vs. 4.9 ± 0.3, p = 0.2) between the glaucoma patients and controls. The significant difference in brachial artery diameter in hyperemia between the glaucoma patients and controls (5.5 ± 0.6 vs. 5.9 ± 0.4 p = 0.002) was found. A negative correlation among brachial FMD and carotid IMT as well as among brachial FMD and brachial artery diameter at rest was found. CONCLUSIONS: Impaired brachial FMD indicates presence of systemic vascular endothelial dysfunction in glaucoma; glaucoma patients with lower values of the brachial FMD are at increased risk of having thickened carotid IMT. BioMed Central 2022-06-23 /pmc/articles/PMC9229099/ /pubmed/35739540 http://dx.doi.org/10.1186/s12886-022-02498-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Bojic, Lovro Rogosic, Veljko Markovic, Domagoj Rogosic, Lucija Vanjaka Glavas, Duska Brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients |
title | Brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients |
title_full | Brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients |
title_fullStr | Brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients |
title_full_unstemmed | Brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients |
title_short | Brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients |
title_sort | brachial flow—mediated dilation and carotid intima—media thickness in glaucoma patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229099/ https://www.ncbi.nlm.nih.gov/pubmed/35739540 http://dx.doi.org/10.1186/s12886-022-02498-5 |
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