Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance

BACKGROUND: Chromatin states and enhancers associate gene expression, cell identity and disease. Here, we systematically delineate the acute innate immune response to endotoxin in terms of human macrophage enhancer activity and contrast with endotoxin tolerance, profiling the coding and non-coding t...

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Detalles Bibliográficos
Autores principales: Zhang, Ping, Amarasinghe, Harindra E., Whalley, Justin P., Tay, Chwen, Fang, Hai, Migliorini, Gabriele, Brown, Andrew C., Allcock, Alice, Scozzafava, Giuseppe, Rath, Phalguni, Davies, Benjamin, Knight, Julian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229144/
https://www.ncbi.nlm.nih.gov/pubmed/35751107
http://dx.doi.org/10.1186/s13059-022-02702-1

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