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Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study
MRI-detected inflammation around the extensor tendons of metacarpophalangeal (MCP-) joints is prevalent in RA and poses a markedly increased risk of RA development when present in arthralgia patients. Such inflammation is called ‘peritendinitis’ since anatomy literature reports no presence of a teno...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229148/ https://www.ncbi.nlm.nih.gov/pubmed/35751088 http://dx.doi.org/10.1186/s13075-022-02841-7 |
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author | Dakkak, Yousra J. van Dijk, Bastiaan T. Jansen, Friso P. Wisse, Lambertus J. Reijnierse, Monique van der Helm-van Mil, Annette H. M. DeRuiter, Marco C. |
author_facet | Dakkak, Yousra J. van Dijk, Bastiaan T. Jansen, Friso P. Wisse, Lambertus J. Reijnierse, Monique van der Helm-van Mil, Annette H. M. DeRuiter, Marco C. |
author_sort | Dakkak, Yousra J. |
collection | PubMed |
description | MRI-detected inflammation around the extensor tendons of metacarpophalangeal (MCP-) joints is prevalent in RA and poses a markedly increased risk of RA development when present in arthralgia patients. Such inflammation is called ‘peritendinitis’ since anatomy literature reports no presence of a tenosynovial sheath at these tendons. However, the presence or absence of tenosynovium at these extensor tendons has never been studied. Therefore, an anatomical and histological study of extensor tendons at the MCP-joints of three embalmed human hands was performed. Immunohistochemical staining showed the presence of markers for synovial macrophages and fibroblast-like synoviocytes bordering a natural dorsal space next to the extensor tendon, suggesting the presence of a synovial lining. This implies that contrast-enhancement on MRI around extensor tendons at MCP-joints observed in early RA and pre-RA likely represents tenosynovitis and that inflammation of this synovial tissue is an early feature of RA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-022-02841-7. |
format | Online Article Text |
id | pubmed-9229148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-92291482022-06-25 Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study Dakkak, Yousra J. van Dijk, Bastiaan T. Jansen, Friso P. Wisse, Lambertus J. Reijnierse, Monique van der Helm-van Mil, Annette H. M. DeRuiter, Marco C. Arthritis Res Ther Letter MRI-detected inflammation around the extensor tendons of metacarpophalangeal (MCP-) joints is prevalent in RA and poses a markedly increased risk of RA development when present in arthralgia patients. Such inflammation is called ‘peritendinitis’ since anatomy literature reports no presence of a tenosynovial sheath at these tendons. However, the presence or absence of tenosynovium at these extensor tendons has never been studied. Therefore, an anatomical and histological study of extensor tendons at the MCP-joints of three embalmed human hands was performed. Immunohistochemical staining showed the presence of markers for synovial macrophages and fibroblast-like synoviocytes bordering a natural dorsal space next to the extensor tendon, suggesting the presence of a synovial lining. This implies that contrast-enhancement on MRI around extensor tendons at MCP-joints observed in early RA and pre-RA likely represents tenosynovitis and that inflammation of this synovial tissue is an early feature of RA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-022-02841-7. BioMed Central 2022-06-24 2022 /pmc/articles/PMC9229148/ /pubmed/35751088 http://dx.doi.org/10.1186/s13075-022-02841-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Letter Dakkak, Yousra J. van Dijk, Bastiaan T. Jansen, Friso P. Wisse, Lambertus J. Reijnierse, Monique van der Helm-van Mil, Annette H. M. DeRuiter, Marco C. Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study |
title | Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study |
title_full | Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study |
title_fullStr | Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study |
title_full_unstemmed | Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study |
title_short | Evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study |
title_sort | evidence for the presence of synovial sheaths surrounding the extensor tendons at the metacarpophalangeal joints: a microscopy study |
topic | Letter |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229148/ https://www.ncbi.nlm.nih.gov/pubmed/35751088 http://dx.doi.org/10.1186/s13075-022-02841-7 |
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