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In Vitro, In Vivo and In Silico Characterization of a Novel Kappa-Opioid Receptor Antagonist

Kappa-opioid receptor (KOR) antagonists are promising innovative therapeutics for the treatment of the central nervous system (CNS) disorders. The new scaffold opioid ligand, Compound A, was originally found as a mu-opioid receptor (MOR) antagonist but its binding/selectivity and activation profile...

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Detalles Bibliográficos
Autores principales:	Puls, Kristina, Olivé-Marti, Aina-Leonor, Pach, Szymon, Pinter, Birgit, Erli, Filippo, Wolber, Gerhard, Spetea, Mariana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229160/ https://www.ncbi.nlm.nih.gov/pubmed/35745598 http://dx.doi.org/10.3390/ph15060680

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