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Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids
Microbes in marine ecosystems are known to produce secondary metabolites. One of which are carotenoids, which have numerous industrial applications, hence their demand will continue to grow. This review highlights the recent research on natural carotenoids produced by marine microorganisms. We discu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229179/ https://www.ncbi.nlm.nih.gov/pubmed/35736155 http://dx.doi.org/10.3390/md20060352 |
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author | Steven, Ray Humaira, Zalfa Natanael, Yosua Dwivany, Fenny M. Trinugroho, Joko P. Dwijayanti, Ari Kristianti, Tati Tallei, Trina Ekawati Emran, Talha Bin Jeon, Heewon Alhumaydhi, Fahad A. Radjasa, Ocky Karna Kim, Bonglee |
author_facet | Steven, Ray Humaira, Zalfa Natanael, Yosua Dwivany, Fenny M. Trinugroho, Joko P. Dwijayanti, Ari Kristianti, Tati Tallei, Trina Ekawati Emran, Talha Bin Jeon, Heewon Alhumaydhi, Fahad A. Radjasa, Ocky Karna Kim, Bonglee |
author_sort | Steven, Ray |
collection | PubMed |
description | Microbes in marine ecosystems are known to produce secondary metabolites. One of which are carotenoids, which have numerous industrial applications, hence their demand will continue to grow. This review highlights the recent research on natural carotenoids produced by marine microorganisms. We discuss the most recent screening approaches for discovering carotenoids, using in vitro methods such as culture-dependent and culture-independent screening, as well as in silico methods, using secondary metabolite Biosynthetic Gene Clusters (smBGCs), which involves the use of various rule-based and machine-learning-based bioinformatics tools. Following that, various carotenoids are addressed, along with their biological activities and metabolic processes involved in carotenoids biosynthesis. Finally, we cover the application of carotenoids in health and pharmaceutical industries, current carotenoids production system, and potential use of synthetic biology in carotenoids production. |
format | Online Article Text |
id | pubmed-9229179 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92291792022-06-25 Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids Steven, Ray Humaira, Zalfa Natanael, Yosua Dwivany, Fenny M. Trinugroho, Joko P. Dwijayanti, Ari Kristianti, Tati Tallei, Trina Ekawati Emran, Talha Bin Jeon, Heewon Alhumaydhi, Fahad A. Radjasa, Ocky Karna Kim, Bonglee Mar Drugs Review Microbes in marine ecosystems are known to produce secondary metabolites. One of which are carotenoids, which have numerous industrial applications, hence their demand will continue to grow. This review highlights the recent research on natural carotenoids produced by marine microorganisms. We discuss the most recent screening approaches for discovering carotenoids, using in vitro methods such as culture-dependent and culture-independent screening, as well as in silico methods, using secondary metabolite Biosynthetic Gene Clusters (smBGCs), which involves the use of various rule-based and machine-learning-based bioinformatics tools. Following that, various carotenoids are addressed, along with their biological activities and metabolic processes involved in carotenoids biosynthesis. Finally, we cover the application of carotenoids in health and pharmaceutical industries, current carotenoids production system, and potential use of synthetic biology in carotenoids production. MDPI 2022-05-26 /pmc/articles/PMC9229179/ /pubmed/35736155 http://dx.doi.org/10.3390/md20060352 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Steven, Ray Humaira, Zalfa Natanael, Yosua Dwivany, Fenny M. Trinugroho, Joko P. Dwijayanti, Ari Kristianti, Tati Tallei, Trina Ekawati Emran, Talha Bin Jeon, Heewon Alhumaydhi, Fahad A. Radjasa, Ocky Karna Kim, Bonglee Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids |
title | Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids |
title_full | Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids |
title_fullStr | Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids |
title_full_unstemmed | Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids |
title_short | Marine Microbial-Derived Resource Exploration: Uncovering the Hidden Potential of Marine Carotenoids |
title_sort | marine microbial-derived resource exploration: uncovering the hidden potential of marine carotenoids |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229179/ https://www.ncbi.nlm.nih.gov/pubmed/35736155 http://dx.doi.org/10.3390/md20060352 |
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