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Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review
Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229182/ https://www.ncbi.nlm.nih.gov/pubmed/35756645 http://dx.doi.org/10.3389/fonc.2022.913217 |
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author | Chen, Minmin Liu, Mengyuan Li, Chenyan Peng, Shiqiao Li, Yiling Xu, Xiuying Sun, Mingjun Sun, Xuren |
author_facet | Chen, Minmin Liu, Mengyuan Li, Chenyan Peng, Shiqiao Li, Yiling Xu, Xiuying Sun, Mingjun Sun, Xuren |
author_sort | Chen, Minmin |
collection | PubMed |
description | Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palatal malignant melanoma who developed diarrhea and hematochezia accompanied by fever, gastrointestinal bleeding, and infection after the third treatment with PD-1 (Toripalimab). The patient received general treatment unsuccessful, corticosteroid therapy after initial success but rapid loss of response, and finally successful treatment after fecal microbiota transplantation. |
format | Online Article Text |
id | pubmed-9229182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92291822022-06-25 Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review Chen, Minmin Liu, Mengyuan Li, Chenyan Peng, Shiqiao Li, Yiling Xu, Xiuying Sun, Mingjun Sun, Xuren Front Oncol Oncology Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palatal malignant melanoma who developed diarrhea and hematochezia accompanied by fever, gastrointestinal bleeding, and infection after the third treatment with PD-1 (Toripalimab). The patient received general treatment unsuccessful, corticosteroid therapy after initial success but rapid loss of response, and finally successful treatment after fecal microbiota transplantation. Frontiers Media S.A. 2022-06-10 /pmc/articles/PMC9229182/ /pubmed/35756645 http://dx.doi.org/10.3389/fonc.2022.913217 Text en Copyright © 2022 Chen, Liu, Li, Peng, Li, Xu, Sun and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chen, Minmin Liu, Mengyuan Li, Chenyan Peng, Shiqiao Li, Yiling Xu, Xiuying Sun, Mingjun Sun, Xuren Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review |
title | Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review |
title_full | Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review |
title_fullStr | Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review |
title_full_unstemmed | Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review |
title_short | Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review |
title_sort | fecal microbiota transplantation effectively cures a patient with severe bleeding immune checkpoint inhibitor-associated colitis and a short review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229182/ https://www.ncbi.nlm.nih.gov/pubmed/35756645 http://dx.doi.org/10.3389/fonc.2022.913217 |
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