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Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review

Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palat...

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Autores principales: Chen, Minmin, Liu, Mengyuan, Li, Chenyan, Peng, Shiqiao, Li, Yiling, Xu, Xiuying, Sun, Mingjun, Sun, Xuren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229182/
https://www.ncbi.nlm.nih.gov/pubmed/35756645
http://dx.doi.org/10.3389/fonc.2022.913217
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author Chen, Minmin
Liu, Mengyuan
Li, Chenyan
Peng, Shiqiao
Li, Yiling
Xu, Xiuying
Sun, Mingjun
Sun, Xuren
author_facet Chen, Minmin
Liu, Mengyuan
Li, Chenyan
Peng, Shiqiao
Li, Yiling
Xu, Xiuying
Sun, Mingjun
Sun, Xuren
author_sort Chen, Minmin
collection PubMed
description Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palatal malignant melanoma who developed diarrhea and hematochezia accompanied by fever, gastrointestinal bleeding, and infection after the third treatment with PD-1 (Toripalimab). The patient received general treatment unsuccessful, corticosteroid therapy after initial success but rapid loss of response, and finally successful treatment after fecal microbiota transplantation.
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spelling pubmed-92291822022-06-25 Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review Chen, Minmin Liu, Mengyuan Li, Chenyan Peng, Shiqiao Li, Yiling Xu, Xiuying Sun, Mingjun Sun, Xuren Front Oncol Oncology Immune checkpoint inhibitors (ICIs) have opened up a new way for tumor therapy but simultaneously led to the occurrence of immune-related adverse events. We report a case of successful treatment of PD-1 inhibitor-associated colitis with fecal microbiota transplantation (FMT). The patient was a palatal malignant melanoma who developed diarrhea and hematochezia accompanied by fever, gastrointestinal bleeding, and infection after the third treatment with PD-1 (Toripalimab). The patient received general treatment unsuccessful, corticosteroid therapy after initial success but rapid loss of response, and finally successful treatment after fecal microbiota transplantation. Frontiers Media S.A. 2022-06-10 /pmc/articles/PMC9229182/ /pubmed/35756645 http://dx.doi.org/10.3389/fonc.2022.913217 Text en Copyright © 2022 Chen, Liu, Li, Peng, Li, Xu, Sun and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Minmin
Liu, Mengyuan
Li, Chenyan
Peng, Shiqiao
Li, Yiling
Xu, Xiuying
Sun, Mingjun
Sun, Xuren
Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review
title Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review
title_full Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review
title_fullStr Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review
title_full_unstemmed Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review
title_short Fecal Microbiota Transplantation Effectively Cures a Patient With Severe Bleeding Immune Checkpoint Inhibitor-Associated Colitis and a Short Review
title_sort fecal microbiota transplantation effectively cures a patient with severe bleeding immune checkpoint inhibitor-associated colitis and a short review
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229182/
https://www.ncbi.nlm.nih.gov/pubmed/35756645
http://dx.doi.org/10.3389/fonc.2022.913217
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