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Rational Design of Microfluidic Glaucoma Stent

Glaucoma is a common, irreparable eye disease associated with high intraocular pressure. One treatment option is implantation of a stent to lower the intraocular pressure. A systematic approach to develop a microchannel stent meshwork that drains aqueous humor from the anterior chamber of the eye in...

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Autores principales: Graf, Thomas, Kancerevycius, Gitanas, Jonušauskas, Linas, Eberle, Patric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229318/
https://www.ncbi.nlm.nih.gov/pubmed/35744591
http://dx.doi.org/10.3390/mi13060978
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author Graf, Thomas
Kancerevycius, Gitanas
Jonušauskas, Linas
Eberle, Patric
author_facet Graf, Thomas
Kancerevycius, Gitanas
Jonušauskas, Linas
Eberle, Patric
author_sort Graf, Thomas
collection PubMed
description Glaucoma is a common, irreparable eye disease associated with high intraocular pressure. One treatment option is implantation of a stent to lower the intraocular pressure. A systematic approach to develop a microchannel stent meshwork that drains aqueous humor from the anterior chamber of the eye into the subconjunctival space is presented. The stent has a large number of outlets within its mesh structure that open into the subconjunctiva. The development approach includes a flow resistance model of the stent. Local adaption of the stent’s tubular dimensions allows for adjustment of the flow resistance. In this way, an evenly distributed outflow into the subconjunctiva is achieved. We anticipate that microblebs will form at the stent outlets. Their size is crucial for drainage and control of intraocular pressure. An analytical model for bleb drainage is developed based on the porous properties of the subconjunctival tissue. Both models—the stent flow resistance model and the bleb drainage model—are verified by numerical simulation. The models and numerical simulation are used to predict intraocular pressure after surgery. They allow for a systematic and personalized design of microchannel stents. Stents designed in this way can stabilize the intraocular pressure between an upper and lower limit.
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spelling pubmed-92293182022-06-25 Rational Design of Microfluidic Glaucoma Stent Graf, Thomas Kancerevycius, Gitanas Jonušauskas, Linas Eberle, Patric Micromachines (Basel) Article Glaucoma is a common, irreparable eye disease associated with high intraocular pressure. One treatment option is implantation of a stent to lower the intraocular pressure. A systematic approach to develop a microchannel stent meshwork that drains aqueous humor from the anterior chamber of the eye into the subconjunctival space is presented. The stent has a large number of outlets within its mesh structure that open into the subconjunctiva. The development approach includes a flow resistance model of the stent. Local adaption of the stent’s tubular dimensions allows for adjustment of the flow resistance. In this way, an evenly distributed outflow into the subconjunctiva is achieved. We anticipate that microblebs will form at the stent outlets. Their size is crucial for drainage and control of intraocular pressure. An analytical model for bleb drainage is developed based on the porous properties of the subconjunctival tissue. Both models—the stent flow resistance model and the bleb drainage model—are verified by numerical simulation. The models and numerical simulation are used to predict intraocular pressure after surgery. They allow for a systematic and personalized design of microchannel stents. Stents designed in this way can stabilize the intraocular pressure between an upper and lower limit. MDPI 2022-06-20 /pmc/articles/PMC9229318/ /pubmed/35744591 http://dx.doi.org/10.3390/mi13060978 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Graf, Thomas
Kancerevycius, Gitanas
Jonušauskas, Linas
Eberle, Patric
Rational Design of Microfluidic Glaucoma Stent
title Rational Design of Microfluidic Glaucoma Stent
title_full Rational Design of Microfluidic Glaucoma Stent
title_fullStr Rational Design of Microfluidic Glaucoma Stent
title_full_unstemmed Rational Design of Microfluidic Glaucoma Stent
title_short Rational Design of Microfluidic Glaucoma Stent
title_sort rational design of microfluidic glaucoma stent
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229318/
https://www.ncbi.nlm.nih.gov/pubmed/35744591
http://dx.doi.org/10.3390/mi13060978
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