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Biomarkers Predictive for In-Hospital Mortality in Patients with Diabetes Mellitus and Prediabetes Hospitalized for COVID-19 in Austria: An Analysis of COVID-19 in Diabetes Registry

Background: This study assessed the predictive performance of inflammatory, hepatic, coagulation, and cardiac biomarkers in patients with prediabetes and diabetes mellitus hospitalized for COVID-19 in Austria. Methods: This was an analysis of a multicenter cohort study of 747 patients with diabetes...

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Autores principales: Aziz, Faisal, Stöcher, Hannah, Bräuer, Alexander, Ciardi, Christian, Clodi, Martin, Fasching, Peter, Karolyi, Mario, Kautzky-Willer, Alexandra, Klammer, Carmen, Malle, Oliver, Aberer, Felix, Pawelka, Erich, Peric, Slobodan, Ress, Claudia, Sourij, Caren, Stechemesser, Lars, Stingl, Harald, Stulnig, Thomas, Tripolt, Norbert, Wagner, Michael, Wolf, Peter, Zitterl, Andreas, Moser, Othmar, Schelkshorn, Christian, Kaser, Susanne, Sourij, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229324/
https://www.ncbi.nlm.nih.gov/pubmed/35746755
http://dx.doi.org/10.3390/v14061285
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author Aziz, Faisal
Stöcher, Hannah
Bräuer, Alexander
Ciardi, Christian
Clodi, Martin
Fasching, Peter
Karolyi, Mario
Kautzky-Willer, Alexandra
Klammer, Carmen
Malle, Oliver
Aberer, Felix
Pawelka, Erich
Peric, Slobodan
Ress, Claudia
Sourij, Caren
Stechemesser, Lars
Stingl, Harald
Stulnig, Thomas
Tripolt, Norbert
Wagner, Michael
Wolf, Peter
Zitterl, Andreas
Moser, Othmar
Schelkshorn, Christian
Kaser, Susanne
Sourij, Harald
author_facet Aziz, Faisal
Stöcher, Hannah
Bräuer, Alexander
Ciardi, Christian
Clodi, Martin
Fasching, Peter
Karolyi, Mario
Kautzky-Willer, Alexandra
Klammer, Carmen
Malle, Oliver
Aberer, Felix
Pawelka, Erich
Peric, Slobodan
Ress, Claudia
Sourij, Caren
Stechemesser, Lars
Stingl, Harald
Stulnig, Thomas
Tripolt, Norbert
Wagner, Michael
Wolf, Peter
Zitterl, Andreas
Moser, Othmar
Schelkshorn, Christian
Kaser, Susanne
Sourij, Harald
author_sort Aziz, Faisal
collection PubMed
description Background: This study assessed the predictive performance of inflammatory, hepatic, coagulation, and cardiac biomarkers in patients with prediabetes and diabetes mellitus hospitalized for COVID-19 in Austria. Methods: This was an analysis of a multicenter cohort study of 747 patients with diabetes mellitus or prediabetes hospitalized for COVID-19 in 11 hospitals in Austria. The primary outcome of this study was in-hospital mortality. The predictor variables included demographic characteristics, clinical parameters, comorbidities, use of medication, disease severity, and laboratory measurements of biomarkers. The association between biomarkers and in-hospital mortality was assessed using simple and multiple logistic regression analyses. The predictive performance of biomarkers was assessed using discrimination and calibration. Results: In our analysis, 70.8% had type 2 diabetes mellitus, 5.8% had type 1 diabetes mellitus, 14.9% had prediabetes, and 8.6% had other types of diabetes mellitus. The mean age was 70.3 ± 13.3 years, and 69.3% of patients were men. A total of 19.0% of patients died in the hospital. In multiple logistic regression analysis, LDH, CRP, IL-6, PCT, AST-ALT ratio, NT-proBNP, and Troponin T were significantly associated with in-hospital mortality. The discrimination of NT-proBNP was 74%, and that of Troponin T was 81%. The calibration of NT-proBNP was adequate (p = 0.302), while it was inadequate for Troponin T (p = 0.010). Conclusion: Troponin T showed excellent predictive performance, while NT-proBNP showed good predictive performance for assessing in-hospital mortality in patients with diabetes mellitus hospitalized with COVID-19. Therefore, these cardiac biomarkers may be used for prognostication of COVID-19 patients.
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spelling pubmed-92293242022-06-25 Biomarkers Predictive for In-Hospital Mortality in Patients with Diabetes Mellitus and Prediabetes Hospitalized for COVID-19 in Austria: An Analysis of COVID-19 in Diabetes Registry Aziz, Faisal Stöcher, Hannah Bräuer, Alexander Ciardi, Christian Clodi, Martin Fasching, Peter Karolyi, Mario Kautzky-Willer, Alexandra Klammer, Carmen Malle, Oliver Aberer, Felix Pawelka, Erich Peric, Slobodan Ress, Claudia Sourij, Caren Stechemesser, Lars Stingl, Harald Stulnig, Thomas Tripolt, Norbert Wagner, Michael Wolf, Peter Zitterl, Andreas Moser, Othmar Schelkshorn, Christian Kaser, Susanne Sourij, Harald Viruses Article Background: This study assessed the predictive performance of inflammatory, hepatic, coagulation, and cardiac biomarkers in patients with prediabetes and diabetes mellitus hospitalized for COVID-19 in Austria. Methods: This was an analysis of a multicenter cohort study of 747 patients with diabetes mellitus or prediabetes hospitalized for COVID-19 in 11 hospitals in Austria. The primary outcome of this study was in-hospital mortality. The predictor variables included demographic characteristics, clinical parameters, comorbidities, use of medication, disease severity, and laboratory measurements of biomarkers. The association between biomarkers and in-hospital mortality was assessed using simple and multiple logistic regression analyses. The predictive performance of biomarkers was assessed using discrimination and calibration. Results: In our analysis, 70.8% had type 2 diabetes mellitus, 5.8% had type 1 diabetes mellitus, 14.9% had prediabetes, and 8.6% had other types of diabetes mellitus. The mean age was 70.3 ± 13.3 years, and 69.3% of patients were men. A total of 19.0% of patients died in the hospital. In multiple logistic regression analysis, LDH, CRP, IL-6, PCT, AST-ALT ratio, NT-proBNP, and Troponin T were significantly associated with in-hospital mortality. The discrimination of NT-proBNP was 74%, and that of Troponin T was 81%. The calibration of NT-proBNP was adequate (p = 0.302), while it was inadequate for Troponin T (p = 0.010). Conclusion: Troponin T showed excellent predictive performance, while NT-proBNP showed good predictive performance for assessing in-hospital mortality in patients with diabetes mellitus hospitalized with COVID-19. Therefore, these cardiac biomarkers may be used for prognostication of COVID-19 patients. MDPI 2022-06-13 /pmc/articles/PMC9229324/ /pubmed/35746755 http://dx.doi.org/10.3390/v14061285 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aziz, Faisal
Stöcher, Hannah
Bräuer, Alexander
Ciardi, Christian
Clodi, Martin
Fasching, Peter
Karolyi, Mario
Kautzky-Willer, Alexandra
Klammer, Carmen
Malle, Oliver
Aberer, Felix
Pawelka, Erich
Peric, Slobodan
Ress, Claudia
Sourij, Caren
Stechemesser, Lars
Stingl, Harald
Stulnig, Thomas
Tripolt, Norbert
Wagner, Michael
Wolf, Peter
Zitterl, Andreas
Moser, Othmar
Schelkshorn, Christian
Kaser, Susanne
Sourij, Harald
Biomarkers Predictive for In-Hospital Mortality in Patients with Diabetes Mellitus and Prediabetes Hospitalized for COVID-19 in Austria: An Analysis of COVID-19 in Diabetes Registry
title Biomarkers Predictive for In-Hospital Mortality in Patients with Diabetes Mellitus and Prediabetes Hospitalized for COVID-19 in Austria: An Analysis of COVID-19 in Diabetes Registry
title_full Biomarkers Predictive for In-Hospital Mortality in Patients with Diabetes Mellitus and Prediabetes Hospitalized for COVID-19 in Austria: An Analysis of COVID-19 in Diabetes Registry
title_fullStr Biomarkers Predictive for In-Hospital Mortality in Patients with Diabetes Mellitus and Prediabetes Hospitalized for COVID-19 in Austria: An Analysis of COVID-19 in Diabetes Registry
title_full_unstemmed Biomarkers Predictive for In-Hospital Mortality in Patients with Diabetes Mellitus and Prediabetes Hospitalized for COVID-19 in Austria: An Analysis of COVID-19 in Diabetes Registry
title_short Biomarkers Predictive for In-Hospital Mortality in Patients with Diabetes Mellitus and Prediabetes Hospitalized for COVID-19 in Austria: An Analysis of COVID-19 in Diabetes Registry
title_sort biomarkers predictive for in-hospital mortality in patients with diabetes mellitus and prediabetes hospitalized for covid-19 in austria: an analysis of covid-19 in diabetes registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229324/
https://www.ncbi.nlm.nih.gov/pubmed/35746755
http://dx.doi.org/10.3390/v14061285
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