WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson’s Disease Monocytes

Both leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GCase) are promising targets for the treatment of Parkinson’s disease (PD). Evidence suggests that both proteins are involved in biological pathways involving the lysosome. However, studies to date have largely investigated the enzyme...

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Detalles Bibliográficos
Autores principales: Wallings, Rebecca L., Hughes, Laura P., Staley, Hannah A., Simon, Zachary D., McFarland, Nikolaus R., Alcalay, Roy N., Garrido, Alicia, Martí, María José, Sarró, Eduardo Tolosa, Dzamko, Nicolas, Tansey, Malú Gámez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229349/
https://www.ncbi.nlm.nih.gov/pubmed/35755775
http://dx.doi.org/10.3389/fncel.2022.892899

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