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Facile Synthesized Cu–RGO and Ag–RGO Nanocomposites with Potential Biomedical Applications

In the present study, we report on the facile prepared nanocomposites of reduced graphene oxide RGO with Cu and Ag. The synthesis was performed through an environmentally friendly and easy method by simultaneous reduction in solutions containing Cu(2+) or Ag(+) and graphene oxide (GO) using zinc pow...

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Autores principales: Kichukova, Diana, Spassova, Ivanka, Kostadinova, Aneliya, Staneva, Anna, Kovacheva, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229401/
https://www.ncbi.nlm.nih.gov/pubmed/35745432
http://dx.doi.org/10.3390/nano12122096
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author Kichukova, Diana
Spassova, Ivanka
Kostadinova, Aneliya
Staneva, Anna
Kovacheva, Daniela
author_facet Kichukova, Diana
Spassova, Ivanka
Kostadinova, Aneliya
Staneva, Anna
Kovacheva, Daniela
author_sort Kichukova, Diana
collection PubMed
description In the present study, we report on the facile prepared nanocomposites of reduced graphene oxide RGO with Cu and Ag. The synthesis was performed through an environmentally friendly and easy method by simultaneous reduction in solutions containing Cu(2+) or Ag(+) and graphene oxide (GO) using zinc powder as a reducing agent in aqueous acidic media. The composites are characterized by powder X-ray diffraction, low-temperature nitrogen adsorption, X-ray photoelectron and FTIR and Raman spectroscopies, as well as Scanning and Transmission electron microscopies. The antibacterial activity of the composites was tested for Staphylococcus aureus, Escherichia coli and antifungal activity for Candida albicans. The cytotoxicity of the materials was studied towards two types of eukaryotic cells—MDCK II and A549 cell lines. The composites obtained consist of homogeneously distributed Cu and Ag nanoparticles on the surface of graphene sheets and manifest good antimicrobial activity and high cytotoxicity. The results clearly show that both metal–RGO composites can be successfully used as antimicrobial and anticancer agents.
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spelling pubmed-92294012022-06-25 Facile Synthesized Cu–RGO and Ag–RGO Nanocomposites with Potential Biomedical Applications Kichukova, Diana Spassova, Ivanka Kostadinova, Aneliya Staneva, Anna Kovacheva, Daniela Nanomaterials (Basel) Article In the present study, we report on the facile prepared nanocomposites of reduced graphene oxide RGO with Cu and Ag. The synthesis was performed through an environmentally friendly and easy method by simultaneous reduction in solutions containing Cu(2+) or Ag(+) and graphene oxide (GO) using zinc powder as a reducing agent in aqueous acidic media. The composites are characterized by powder X-ray diffraction, low-temperature nitrogen adsorption, X-ray photoelectron and FTIR and Raman spectroscopies, as well as Scanning and Transmission electron microscopies. The antibacterial activity of the composites was tested for Staphylococcus aureus, Escherichia coli and antifungal activity for Candida albicans. The cytotoxicity of the materials was studied towards two types of eukaryotic cells—MDCK II and A549 cell lines. The composites obtained consist of homogeneously distributed Cu and Ag nanoparticles on the surface of graphene sheets and manifest good antimicrobial activity and high cytotoxicity. The results clearly show that both metal–RGO composites can be successfully used as antimicrobial and anticancer agents. MDPI 2022-06-17 /pmc/articles/PMC9229401/ /pubmed/35745432 http://dx.doi.org/10.3390/nano12122096 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kichukova, Diana
Spassova, Ivanka
Kostadinova, Aneliya
Staneva, Anna
Kovacheva, Daniela
Facile Synthesized Cu–RGO and Ag–RGO Nanocomposites with Potential Biomedical Applications
title Facile Synthesized Cu–RGO and Ag–RGO Nanocomposites with Potential Biomedical Applications
title_full Facile Synthesized Cu–RGO and Ag–RGO Nanocomposites with Potential Biomedical Applications
title_fullStr Facile Synthesized Cu–RGO and Ag–RGO Nanocomposites with Potential Biomedical Applications
title_full_unstemmed Facile Synthesized Cu–RGO and Ag–RGO Nanocomposites with Potential Biomedical Applications
title_short Facile Synthesized Cu–RGO and Ag–RGO Nanocomposites with Potential Biomedical Applications
title_sort facile synthesized cu–rgo and ag–rgo nanocomposites with potential biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229401/
https://www.ncbi.nlm.nih.gov/pubmed/35745432
http://dx.doi.org/10.3390/nano12122096
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