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Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review

BACKGROUND: Primary clear cell adenocarcinoma of the urethra is extremely rare, reported only in single case reports, and its histological origin is not clear. There is no standard treatment for CCAU at present, and surgery is still the main treatment for CCAU without distant metastasis. CASE PRESEN...

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Autores principales: Miao, Jianguang, Hu, Jiebin, Wu, Jilin, Guo, Wei, Chen, Jinbo, Li, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229477/
https://www.ncbi.nlm.nih.gov/pubmed/35751118
http://dx.doi.org/10.1186/s12905-022-01835-6
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author Miao, Jianguang
Hu, Jiebin
Wu, Jilin
Guo, Wei
Chen, Jinbo
Li, Jin
author_facet Miao, Jianguang
Hu, Jiebin
Wu, Jilin
Guo, Wei
Chen, Jinbo
Li, Jin
author_sort Miao, Jianguang
collection PubMed
description BACKGROUND: Primary clear cell adenocarcinoma of the urethra is extremely rare, reported only in single case reports, and its histological origin is not clear. There is no standard treatment for CCAU at present, and surgery is still the main treatment for CCAU without distant metastasis. CASE PRESENTATION: A 67-year-old female complained of gross hematuria with frequent micturition and urgency. No urethral diverticulum was found by cystoscopy or MRI, and the mass grew around the urethra. Urethral and anterior pelvic viscera resection was performed. Clear cell adenocarcinoma was confirmed by immunohistochemistry after the operation, and no recurrence or metastasis was found after one year of follow-up. CONCLUSION: CCAU is very rare, and most cases originate from the urethral diverticulum and some may also originate from tissues around the urethra. For CCAU patients without distant metastasis, the main treatment is still surgery, and radiotherapy and chemotherapy can be performed for patients with distant metastasis. Gene detection may provide guidance for the precise chemotherapy of CCAU.
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spelling pubmed-92294772022-06-25 Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review Miao, Jianguang Hu, Jiebin Wu, Jilin Guo, Wei Chen, Jinbo Li, Jin BMC Womens Health Case Report BACKGROUND: Primary clear cell adenocarcinoma of the urethra is extremely rare, reported only in single case reports, and its histological origin is not clear. There is no standard treatment for CCAU at present, and surgery is still the main treatment for CCAU without distant metastasis. CASE PRESENTATION: A 67-year-old female complained of gross hematuria with frequent micturition and urgency. No urethral diverticulum was found by cystoscopy or MRI, and the mass grew around the urethra. Urethral and anterior pelvic viscera resection was performed. Clear cell adenocarcinoma was confirmed by immunohistochemistry after the operation, and no recurrence or metastasis was found after one year of follow-up. CONCLUSION: CCAU is very rare, and most cases originate from the urethral diverticulum and some may also originate from tissues around the urethra. For CCAU patients without distant metastasis, the main treatment is still surgery, and radiotherapy and chemotherapy can be performed for patients with distant metastasis. Gene detection may provide guidance for the precise chemotherapy of CCAU. BioMed Central 2022-06-24 /pmc/articles/PMC9229477/ /pubmed/35751118 http://dx.doi.org/10.1186/s12905-022-01835-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Miao, Jianguang
Hu, Jiebin
Wu, Jilin
Guo, Wei
Chen, Jinbo
Li, Jin
Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review
title Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review
title_full Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review
title_fullStr Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review
title_full_unstemmed Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review
title_short Primary clear cell adenocarcinoma of female urinary tract: a case report and literature review
title_sort primary clear cell adenocarcinoma of female urinary tract: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229477/
https://www.ncbi.nlm.nih.gov/pubmed/35751118
http://dx.doi.org/10.1186/s12905-022-01835-6
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