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Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial

Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle...

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Autores principales: Kempf, Kerstin, Röhling, Martin, Banzer, Winfried, Braumann, Klaus Michael, Halle, Martin, Schaller, Nina, McCarthy, David, Predel, Hans Georg, Schenkenberger, Isabelle, Tan, Susanne, Toplak, Hermann, Martin, Stephan, Berg, Aloys
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229506/
https://www.ncbi.nlm.nih.gov/pubmed/35745267
http://dx.doi.org/10.3390/nu14122537
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author Kempf, Kerstin
Röhling, Martin
Banzer, Winfried
Braumann, Klaus Michael
Halle, Martin
Schaller, Nina
McCarthy, David
Predel, Hans Georg
Schenkenberger, Isabelle
Tan, Susanne
Toplak, Hermann
Martin, Stephan
Berg, Aloys
author_facet Kempf, Kerstin
Röhling, Martin
Banzer, Winfried
Braumann, Klaus Michael
Halle, Martin
Schaller, Nina
McCarthy, David
Predel, Hans Georg
Schenkenberger, Isabelle
Tan, Susanne
Toplak, Hermann
Martin, Stephan
Berg, Aloys
author_sort Kempf, Kerstin
collection PubMed
description Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria (n = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data (n = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline (p < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference −3.4 µg/L [1.4; 5.4] for females; −2.2 µg/L [1.2; 3.3] for males; p < 0.001 each) and was predictive for stronger reduction of body weight and fat mass (p < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (−5.9 ± 5.1 kg in females of the intervention group vs. −2.9 ± 4.9 kg in the control group (p < 0.0001); −6.8 ± 5.3 kg vs. −4.1 ± 4.4 kg (p = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss.
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spelling pubmed-92295062022-06-25 Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial Kempf, Kerstin Röhling, Martin Banzer, Winfried Braumann, Klaus Michael Halle, Martin Schaller, Nina McCarthy, David Predel, Hans Georg Schenkenberger, Isabelle Tan, Susanne Toplak, Hermann Martin, Stephan Berg, Aloys Nutrients Article Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria (n = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data (n = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline (p < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference −3.4 µg/L [1.4; 5.4] for females; −2.2 µg/L [1.2; 3.3] for males; p < 0.001 each) and was predictive for stronger reduction of body weight and fat mass (p < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (−5.9 ± 5.1 kg in females of the intervention group vs. −2.9 ± 4.9 kg in the control group (p < 0.0001); −6.8 ± 5.3 kg vs. −4.1 ± 4.4 kg (p = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss. MDPI 2022-06-18 /pmc/articles/PMC9229506/ /pubmed/35745267 http://dx.doi.org/10.3390/nu14122537 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kempf, Kerstin
Röhling, Martin
Banzer, Winfried
Braumann, Klaus Michael
Halle, Martin
Schaller, Nina
McCarthy, David
Predel, Hans Georg
Schenkenberger, Isabelle
Tan, Susanne
Toplak, Hermann
Martin, Stephan
Berg, Aloys
Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial
title Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial
title_full Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial
title_fullStr Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial
title_full_unstemmed Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial
title_short Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial
title_sort early and strong leptin reduction is predictive for long-term weight loss during high-protein, low-glycaemic meal replacement—a subanalysis of the randomised-controlled acoorh trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229506/
https://www.ncbi.nlm.nih.gov/pubmed/35745267
http://dx.doi.org/10.3390/nu14122537
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