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Low Luteal Serum Progesterone Levels Are Associated With Lower Ongoing Pregnancy and Live Birth Rates in ART: Systematic Review and Meta-Analyses

Progesterone plays a key role in implantation. Several studies reported that lower luteal progesterone levels might be related to decreased chances of pregnancy. This systematic review was conducted using appropriate key words, on MEDLINE, EMBASE, and the Cochrane Library, from 1990 up to March 2021...

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Autores principales: Ranisavljevic, Noemie, Huberlant, Stephanie, Montagut, Marie, Alonzo, Pierre-Marie, Darné, Bernadette, Languille, Solène, Anahory, Tal, Cédrin-Durnerin, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229589/
https://www.ncbi.nlm.nih.gov/pubmed/35757393
http://dx.doi.org/10.3389/fendo.2022.892753
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author Ranisavljevic, Noemie
Huberlant, Stephanie
Montagut, Marie
Alonzo, Pierre-Marie
Darné, Bernadette
Languille, Solène
Anahory, Tal
Cédrin-Durnerin, Isabelle
author_facet Ranisavljevic, Noemie
Huberlant, Stephanie
Montagut, Marie
Alonzo, Pierre-Marie
Darné, Bernadette
Languille, Solène
Anahory, Tal
Cédrin-Durnerin, Isabelle
author_sort Ranisavljevic, Noemie
collection PubMed
description Progesterone plays a key role in implantation. Several studies reported that lower luteal progesterone levels might be related to decreased chances of pregnancy. This systematic review was conducted using appropriate key words, on MEDLINE, EMBASE, and the Cochrane Library, from 1990 up to March 2021 to assess if luteal serum progesterone levels are associated with ongoing pregnancy (OP) and live birth (LB) rates (primary outcomes) and miscarriage rate (secondary outcome), according to the number of corpora lutea (CLs). Overall 2,632 non-duplicate records were identified, of which 32 relevant studies were available for quantitative analysis. In artificial cycles with no CL, OP and LB rates were significantly decreased when the luteal progesterone level falls below a certain threshold (risk ratio [RR] 0.72; 95% confidence interval [CI] 0.62–0.84 and 0.73; 95% CI 0.59–0.90, respectively), while the miscarriage rate was increased (RR 1.48; 95% CI 1.17–1.86). In stimulated cycles with several CLs, the mean luteal progesterone level in the no OP and no LB groups was significantly lower than in the OP and LB groups [difference in means 68.8 (95% CI 45.6–92.0) and 272.4 (95% CI 10.8–533.9), ng/ml, respectively]. Monitoring luteal serum progesterone levels could help in individualizing progesterone administration to enhance OP and LB rates, especially in cycles without corpus luteum. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=139019, identifier 139019.
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spelling pubmed-92295892022-06-25 Low Luteal Serum Progesterone Levels Are Associated With Lower Ongoing Pregnancy and Live Birth Rates in ART: Systematic Review and Meta-Analyses Ranisavljevic, Noemie Huberlant, Stephanie Montagut, Marie Alonzo, Pierre-Marie Darné, Bernadette Languille, Solène Anahory, Tal Cédrin-Durnerin, Isabelle Front Endocrinol (Lausanne) Endocrinology Progesterone plays a key role in implantation. Several studies reported that lower luteal progesterone levels might be related to decreased chances of pregnancy. This systematic review was conducted using appropriate key words, on MEDLINE, EMBASE, and the Cochrane Library, from 1990 up to March 2021 to assess if luteal serum progesterone levels are associated with ongoing pregnancy (OP) and live birth (LB) rates (primary outcomes) and miscarriage rate (secondary outcome), according to the number of corpora lutea (CLs). Overall 2,632 non-duplicate records were identified, of which 32 relevant studies were available for quantitative analysis. In artificial cycles with no CL, OP and LB rates were significantly decreased when the luteal progesterone level falls below a certain threshold (risk ratio [RR] 0.72; 95% confidence interval [CI] 0.62–0.84 and 0.73; 95% CI 0.59–0.90, respectively), while the miscarriage rate was increased (RR 1.48; 95% CI 1.17–1.86). In stimulated cycles with several CLs, the mean luteal progesterone level in the no OP and no LB groups was significantly lower than in the OP and LB groups [difference in means 68.8 (95% CI 45.6–92.0) and 272.4 (95% CI 10.8–533.9), ng/ml, respectively]. Monitoring luteal serum progesterone levels could help in individualizing progesterone administration to enhance OP and LB rates, especially in cycles without corpus luteum. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=139019, identifier 139019. Frontiers Media S.A. 2022-06-10 /pmc/articles/PMC9229589/ /pubmed/35757393 http://dx.doi.org/10.3389/fendo.2022.892753 Text en Copyright © 2022 Ranisavljevic, Huberlant, Montagut, Alonzo, Darné, Languille, Anahory and Cédrin-Durnerin https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ranisavljevic, Noemie
Huberlant, Stephanie
Montagut, Marie
Alonzo, Pierre-Marie
Darné, Bernadette
Languille, Solène
Anahory, Tal
Cédrin-Durnerin, Isabelle
Low Luteal Serum Progesterone Levels Are Associated With Lower Ongoing Pregnancy and Live Birth Rates in ART: Systematic Review and Meta-Analyses
title Low Luteal Serum Progesterone Levels Are Associated With Lower Ongoing Pregnancy and Live Birth Rates in ART: Systematic Review and Meta-Analyses
title_full Low Luteal Serum Progesterone Levels Are Associated With Lower Ongoing Pregnancy and Live Birth Rates in ART: Systematic Review and Meta-Analyses
title_fullStr Low Luteal Serum Progesterone Levels Are Associated With Lower Ongoing Pregnancy and Live Birth Rates in ART: Systematic Review and Meta-Analyses
title_full_unstemmed Low Luteal Serum Progesterone Levels Are Associated With Lower Ongoing Pregnancy and Live Birth Rates in ART: Systematic Review and Meta-Analyses
title_short Low Luteal Serum Progesterone Levels Are Associated With Lower Ongoing Pregnancy and Live Birth Rates in ART: Systematic Review and Meta-Analyses
title_sort low luteal serum progesterone levels are associated with lower ongoing pregnancy and live birth rates in art: systematic review and meta-analyses
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229589/
https://www.ncbi.nlm.nih.gov/pubmed/35757393
http://dx.doi.org/10.3389/fendo.2022.892753
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