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Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes
Mitochondria are surrounded by two membranes; the outer mitochondrial membrane and the inner mitochondrial membrane. They are unique organelles since they have their own DNA, the mitochondrial DNA (mtDNA), which is replicated continuously. Mitochondrial membranes have direct interaction with mtDNA a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229594/ https://www.ncbi.nlm.nih.gov/pubmed/35736332 http://dx.doi.org/10.3390/membranes12060625 |
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author | Almannai, Mohammed Salah, Azza El-Hattab, Ayman W. |
author_facet | Almannai, Mohammed Salah, Azza El-Hattab, Ayman W. |
author_sort | Almannai, Mohammed |
collection | PubMed |
description | Mitochondria are surrounded by two membranes; the outer mitochondrial membrane and the inner mitochondrial membrane. They are unique organelles since they have their own DNA, the mitochondrial DNA (mtDNA), which is replicated continuously. Mitochondrial membranes have direct interaction with mtDNA and are therefore involved in organization of the mitochondrial genome. They also play essential roles in mitochondrial dynamics and the supply of nucleotides for mtDNA synthesis. In this review, we will discuss how the mitochondrial membranes interact with mtDNA and how this interaction is essential for mtDNA maintenance. We will review different mtDNA maintenance disorders that result from defects in this crucial interaction. Finally, we will review therapeutic approaches relevant to defects in mitochondrial membranes. |
format | Online Article Text |
id | pubmed-9229594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92295942022-06-25 Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes Almannai, Mohammed Salah, Azza El-Hattab, Ayman W. Membranes (Basel) Review Mitochondria are surrounded by two membranes; the outer mitochondrial membrane and the inner mitochondrial membrane. They are unique organelles since they have their own DNA, the mitochondrial DNA (mtDNA), which is replicated continuously. Mitochondrial membranes have direct interaction with mtDNA and are therefore involved in organization of the mitochondrial genome. They also play essential roles in mitochondrial dynamics and the supply of nucleotides for mtDNA synthesis. In this review, we will discuss how the mitochondrial membranes interact with mtDNA and how this interaction is essential for mtDNA maintenance. We will review different mtDNA maintenance disorders that result from defects in this crucial interaction. Finally, we will review therapeutic approaches relevant to defects in mitochondrial membranes. MDPI 2022-06-15 /pmc/articles/PMC9229594/ /pubmed/35736332 http://dx.doi.org/10.3390/membranes12060625 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Almannai, Mohammed Salah, Azza El-Hattab, Ayman W. Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
title | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
title_full | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
title_fullStr | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
title_full_unstemmed | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
title_short | Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes |
title_sort | mitochondrial membranes and mitochondrial genome: interactions and clinical syndromes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229594/ https://www.ncbi.nlm.nih.gov/pubmed/35736332 http://dx.doi.org/10.3390/membranes12060625 |
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