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In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review

Boron nitride nanotubes (BNNTs) are an exciting class of nanomaterials due to their unique chemical and physical characteristics. In recent decades, BNNTs have gained huge attention in research and development for various applications, including as nano-fillers for composites, semiconductor devices,...

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Autores principales: Kakarla, Akesh Babu, Kong, Ing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229602/
https://www.ncbi.nlm.nih.gov/pubmed/35745407
http://dx.doi.org/10.3390/nano12122069
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author Kakarla, Akesh Babu
Kong, Ing
author_facet Kakarla, Akesh Babu
Kong, Ing
author_sort Kakarla, Akesh Babu
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description Boron nitride nanotubes (BNNTs) are an exciting class of nanomaterials due to their unique chemical and physical characteristics. In recent decades, BNNTs have gained huge attention in research and development for various applications, including as nano-fillers for composites, semiconductor devices, hydrogen storage, and as an emerging material in biomedical and tissue engineering applications. However, the toxicity of BNNTs is not clear, and the biocompatibility is not proven yet. In this review, the role of BNNTs in biocompatibility studies is assessed in terms of their characteristics: cell viability, proliferation, therapeutic outcomes, and genotoxicity, which are vital elements for their prospective use in biomedical applications. A systematic review was conducted utilising the databases Scopus and Web of Science (WOS) (2008–2022). Additional findings were discovered manually by snowballing the reference lists of appropriate reviews. Only English-language articles were included. Finally, the significant analysis and discussion of the chosen articles are presented.
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spelling pubmed-92296022022-06-25 In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review Kakarla, Akesh Babu Kong, Ing Nanomaterials (Basel) Review Boron nitride nanotubes (BNNTs) are an exciting class of nanomaterials due to their unique chemical and physical characteristics. In recent decades, BNNTs have gained huge attention in research and development for various applications, including as nano-fillers for composites, semiconductor devices, hydrogen storage, and as an emerging material in biomedical and tissue engineering applications. However, the toxicity of BNNTs is not clear, and the biocompatibility is not proven yet. In this review, the role of BNNTs in biocompatibility studies is assessed in terms of their characteristics: cell viability, proliferation, therapeutic outcomes, and genotoxicity, which are vital elements for their prospective use in biomedical applications. A systematic review was conducted utilising the databases Scopus and Web of Science (WOS) (2008–2022). Additional findings were discovered manually by snowballing the reference lists of appropriate reviews. Only English-language articles were included. Finally, the significant analysis and discussion of the chosen articles are presented. MDPI 2022-06-15 /pmc/articles/PMC9229602/ /pubmed/35745407 http://dx.doi.org/10.3390/nano12122069 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kakarla, Akesh Babu
Kong, Ing
In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review
title In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review
title_full In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review
title_fullStr In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review
title_full_unstemmed In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review
title_short In Vitro and In Vivo Cytotoxicity of Boron Nitride Nanotubes: A Systematic Review
title_sort in vitro and in vivo cytotoxicity of boron nitride nanotubes: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229602/
https://www.ncbi.nlm.nih.gov/pubmed/35745407
http://dx.doi.org/10.3390/nano12122069
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