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Pulmonary Embolism after Moderna Vaccination in Kidney Transplant Patients: Two Case Reports and Literature Review

Currently, the coronavirus disease 2019 (COVID-19) pandemic is still an ongoing and constant medical issue, and with upcoming new variants, vaccinations and boosters remain important. The safety of vaccines in patients after kidney transplantation is an essential problem, with thrombosis being one o...

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Autores principales: Chan, Wai-Nga, Chen, Chih-Shou, Ho, Dong-Ru, Huang, Yun-Ching, Lin, Jian-Hui, Huang, Kuo-Tsai, Liu, Yu-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229759/
https://www.ncbi.nlm.nih.gov/pubmed/35746476
http://dx.doi.org/10.3390/vaccines10060868
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author Chan, Wai-Nga
Chen, Chih-Shou
Ho, Dong-Ru
Huang, Yun-Ching
Lin, Jian-Hui
Huang, Kuo-Tsai
Liu, Yu-Liang
author_facet Chan, Wai-Nga
Chen, Chih-Shou
Ho, Dong-Ru
Huang, Yun-Ching
Lin, Jian-Hui
Huang, Kuo-Tsai
Liu, Yu-Liang
author_sort Chan, Wai-Nga
collection PubMed
description Currently, the coronavirus disease 2019 (COVID-19) pandemic is still an ongoing and constant medical issue, and with upcoming new variants, vaccinations and boosters remain important. The safety of vaccines in patients after kidney transplantation is an essential problem, with thrombosis being one of the severe side effects and vaccine-induced immune thrombotic thrombocytopenia (VITT) revealed as the most commonly reported syndrome for thromboembolic events following COVID-19 vaccination. Here, we present two cases of kidney transplantation developing pulmonary embolism post-Moderna vaccination within 30 days without thrombocytopenia. The first case was a 52-year-old man with history of type II diabetes, hypertension and hyperlipidemia who had had cadaveric kidney transplantation in September 2008, where right leg swelling with claudication occurred 23 days after the second Moderna vaccination. The second case was a 57-year-old man with history of type II diabetes and glaucoma who had had living-related kidney transplantation in April 2013 and then complained of exertional dyspnea 26 days after administration of the third Moderna vaccine. The advantages of vaccination even in immunocompromised patients far outweigh the disadvantages, although clinicians must understand the risks of deep-vein thrombosis or even pulmonary embolism for such patients, which might not occur after just the first vaccination.
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spelling pubmed-92297592022-06-25 Pulmonary Embolism after Moderna Vaccination in Kidney Transplant Patients: Two Case Reports and Literature Review Chan, Wai-Nga Chen, Chih-Shou Ho, Dong-Ru Huang, Yun-Ching Lin, Jian-Hui Huang, Kuo-Tsai Liu, Yu-Liang Vaccines (Basel) Case Report Currently, the coronavirus disease 2019 (COVID-19) pandemic is still an ongoing and constant medical issue, and with upcoming new variants, vaccinations and boosters remain important. The safety of vaccines in patients after kidney transplantation is an essential problem, with thrombosis being one of the severe side effects and vaccine-induced immune thrombotic thrombocytopenia (VITT) revealed as the most commonly reported syndrome for thromboembolic events following COVID-19 vaccination. Here, we present two cases of kidney transplantation developing pulmonary embolism post-Moderna vaccination within 30 days without thrombocytopenia. The first case was a 52-year-old man with history of type II diabetes, hypertension and hyperlipidemia who had had cadaveric kidney transplantation in September 2008, where right leg swelling with claudication occurred 23 days after the second Moderna vaccination. The second case was a 57-year-old man with history of type II diabetes and glaucoma who had had living-related kidney transplantation in April 2013 and then complained of exertional dyspnea 26 days after administration of the third Moderna vaccine. The advantages of vaccination even in immunocompromised patients far outweigh the disadvantages, although clinicians must understand the risks of deep-vein thrombosis or even pulmonary embolism for such patients, which might not occur after just the first vaccination. MDPI 2022-05-29 /pmc/articles/PMC9229759/ /pubmed/35746476 http://dx.doi.org/10.3390/vaccines10060868 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Chan, Wai-Nga
Chen, Chih-Shou
Ho, Dong-Ru
Huang, Yun-Ching
Lin, Jian-Hui
Huang, Kuo-Tsai
Liu, Yu-Liang
Pulmonary Embolism after Moderna Vaccination in Kidney Transplant Patients: Two Case Reports and Literature Review
title Pulmonary Embolism after Moderna Vaccination in Kidney Transplant Patients: Two Case Reports and Literature Review
title_full Pulmonary Embolism after Moderna Vaccination in Kidney Transplant Patients: Two Case Reports and Literature Review
title_fullStr Pulmonary Embolism after Moderna Vaccination in Kidney Transplant Patients: Two Case Reports and Literature Review
title_full_unstemmed Pulmonary Embolism after Moderna Vaccination in Kidney Transplant Patients: Two Case Reports and Literature Review
title_short Pulmonary Embolism after Moderna Vaccination in Kidney Transplant Patients: Two Case Reports and Literature Review
title_sort pulmonary embolism after moderna vaccination in kidney transplant patients: two case reports and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229759/
https://www.ncbi.nlm.nih.gov/pubmed/35746476
http://dx.doi.org/10.3390/vaccines10060868
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