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Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality

Hantaviruses include several zoonotic pathogens that cause different syndromes in humans, with mortality rates ranging from 12 to 40%. Most commonly, humans get infected through the inhalation of aerosols or dust particles contaminated with virus-containing rodent excreta. Hantaviruses are specifica...

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Autores principales: Leopardi, Stefania, Drzewnioková, Petra, Baggieri, Melissa, Marchi, Antonella, Bucci, Paola, Bregoli, Marco, De Benedictis, Paola, Gobbo, Federica, Bellinati, Laura, Citterio, Carlo, Monne, Isabella, Pastori, Ambra, Zamperin, Gianpiero, Palumbo, Elisa, Festa, Francesca, Castellan, Martina, Zorzan, Maira, D’Ugo, Emilio, Zucca, Paolo, Terregino, Calogero, Magurano, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229784/
https://www.ncbi.nlm.nih.gov/pubmed/35746712
http://dx.doi.org/10.3390/v14061241
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author Leopardi, Stefania
Drzewnioková, Petra
Baggieri, Melissa
Marchi, Antonella
Bucci, Paola
Bregoli, Marco
De Benedictis, Paola
Gobbo, Federica
Bellinati, Laura
Citterio, Carlo
Monne, Isabella
Pastori, Ambra
Zamperin, Gianpiero
Palumbo, Elisa
Festa, Francesca
Castellan, Martina
Zorzan, Maira
D’Ugo, Emilio
Zucca, Paolo
Terregino, Calogero
Magurano, Fabio
author_facet Leopardi, Stefania
Drzewnioková, Petra
Baggieri, Melissa
Marchi, Antonella
Bucci, Paola
Bregoli, Marco
De Benedictis, Paola
Gobbo, Federica
Bellinati, Laura
Citterio, Carlo
Monne, Isabella
Pastori, Ambra
Zamperin, Gianpiero
Palumbo, Elisa
Festa, Francesca
Castellan, Martina
Zorzan, Maira
D’Ugo, Emilio
Zucca, Paolo
Terregino, Calogero
Magurano, Fabio
author_sort Leopardi, Stefania
collection PubMed
description Hantaviruses include several zoonotic pathogens that cause different syndromes in humans, with mortality rates ranging from 12 to 40%. Most commonly, humans get infected through the inhalation of aerosols or dust particles contaminated with virus-containing rodent excreta. Hantaviruses are specifically associated with the host species, and human cases depend on the presence and the dynamics of reservoir hosts. In this letter, we report the identification of Dobrava-Belgrade virus (DOBV) in the yellow-necked mouse (Apodemus flavicollis) from Italy. The virus was detected in the mountainous area of the province of Udine, bordering Austria and Slovenia, during an event of enhanced mortality in wild mice and voles. Despite serological evidence in rodents and humans that suggested the circulation of hantaviruses in Italy since 2000, this is the first virological confirmation of the infection. Phylogenetic analyses across the whole genome of the two detected viruses confirmed the host-specificity of DOBV sub-species and showed the highest identity with viruses identified in Slovenia and Croatia from both A. flavicollis and humans, with no signs of reassortment. These findings highlight the need for ecologists, veterinarians and medical doctors to come together in a coordinated approach in full compliance with the One Health concept.
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spelling pubmed-92297842022-06-25 Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality Leopardi, Stefania Drzewnioková, Petra Baggieri, Melissa Marchi, Antonella Bucci, Paola Bregoli, Marco De Benedictis, Paola Gobbo, Federica Bellinati, Laura Citterio, Carlo Monne, Isabella Pastori, Ambra Zamperin, Gianpiero Palumbo, Elisa Festa, Francesca Castellan, Martina Zorzan, Maira D’Ugo, Emilio Zucca, Paolo Terregino, Calogero Magurano, Fabio Viruses Communication Hantaviruses include several zoonotic pathogens that cause different syndromes in humans, with mortality rates ranging from 12 to 40%. Most commonly, humans get infected through the inhalation of aerosols or dust particles contaminated with virus-containing rodent excreta. Hantaviruses are specifically associated with the host species, and human cases depend on the presence and the dynamics of reservoir hosts. In this letter, we report the identification of Dobrava-Belgrade virus (DOBV) in the yellow-necked mouse (Apodemus flavicollis) from Italy. The virus was detected in the mountainous area of the province of Udine, bordering Austria and Slovenia, during an event of enhanced mortality in wild mice and voles. Despite serological evidence in rodents and humans that suggested the circulation of hantaviruses in Italy since 2000, this is the first virological confirmation of the infection. Phylogenetic analyses across the whole genome of the two detected viruses confirmed the host-specificity of DOBV sub-species and showed the highest identity with viruses identified in Slovenia and Croatia from both A. flavicollis and humans, with no signs of reassortment. These findings highlight the need for ecologists, veterinarians and medical doctors to come together in a coordinated approach in full compliance with the One Health concept. MDPI 2022-06-07 /pmc/articles/PMC9229784/ /pubmed/35746712 http://dx.doi.org/10.3390/v14061241 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Leopardi, Stefania
Drzewnioková, Petra
Baggieri, Melissa
Marchi, Antonella
Bucci, Paola
Bregoli, Marco
De Benedictis, Paola
Gobbo, Federica
Bellinati, Laura
Citterio, Carlo
Monne, Isabella
Pastori, Ambra
Zamperin, Gianpiero
Palumbo, Elisa
Festa, Francesca
Castellan, Martina
Zorzan, Maira
D’Ugo, Emilio
Zucca, Paolo
Terregino, Calogero
Magurano, Fabio
Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality
title Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality
title_full Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality
title_fullStr Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality
title_full_unstemmed Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality
title_short Identification of Dobrava-Belgrade Virus in Apodemus flavicollis from North-Eastern Italy during Enhanced Mortality
title_sort identification of dobrava-belgrade virus in apodemus flavicollis from north-eastern italy during enhanced mortality
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229784/
https://www.ncbi.nlm.nih.gov/pubmed/35746712
http://dx.doi.org/10.3390/v14061241
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