Glycobiology of Cancer: Sugar Drives the Show

Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here...

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Detalles Bibliográficos
Autores principales: dos Reis, Jhenifer Santos, Rodrigues da Costa Santos, Marcos André, Mendonça, Daniella Pereira, Martins do Nascimento, Stefani Ingrid, Barcelos, Pedro Marçal, Correia de Lima, Rafaela Gomes, da Costa, Kelli Monteiro, Freire-de-Lima, Celio Geraldo, Morrot, Alexandre, Previato, Jose Osvaldo, Mendonça Previato, Lucia, da Fonseca, Leonardo Marques, Freire-de-Lima, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229842/
https://www.ncbi.nlm.nih.gov/pubmed/35736247
http://dx.doi.org/10.3390/medicines9060034
Descripción
Sumario:Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here, we discuss about the importance of glycobiology in modern medicine, taking into account the impact of altered glycan structures expressed in cancer cells as potential glycobiomarkers of disease, as well as on cancer development and progression.

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