Cargando…
Glycobiology of Cancer: Sugar Drives the Show
Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here...
| Autores principales: | , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229842/ https://www.ncbi.nlm.nih.gov/pubmed/35736247 http://dx.doi.org/10.3390/medicines9060034 |
| _version_ | 1784734854677528576 |
|---|---|
| author | dos Reis, Jhenifer Santos Rodrigues da Costa Santos, Marcos André Mendonça, Daniella Pereira Martins do Nascimento, Stefani Ingrid Barcelos, Pedro Marçal Correia de Lima, Rafaela Gomes da Costa, Kelli Monteiro Freire-de-Lima, Celio Geraldo Morrot, Alexandre Previato, Jose Osvaldo Mendonça Previato, Lucia da Fonseca, Leonardo Marques Freire-de-Lima, Leonardo |
| author_facet | dos Reis, Jhenifer Santos Rodrigues da Costa Santos, Marcos André Mendonça, Daniella Pereira Martins do Nascimento, Stefani Ingrid Barcelos, Pedro Marçal Correia de Lima, Rafaela Gomes da Costa, Kelli Monteiro Freire-de-Lima, Celio Geraldo Morrot, Alexandre Previato, Jose Osvaldo Mendonça Previato, Lucia da Fonseca, Leonardo Marques Freire-de-Lima, Leonardo |
| author_sort | dos Reis, Jhenifer Santos |
| collection | PubMed |
| description | Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here, we discuss about the importance of glycobiology in modern medicine, taking into account the impact of altered glycan structures expressed in cancer cells as potential glycobiomarkers of disease, as well as on cancer development and progression. |
| format | Online Article Text |
| id | pubmed-9229842 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-92298422022-06-25 Glycobiology of Cancer: Sugar Drives the Show dos Reis, Jhenifer Santos Rodrigues da Costa Santos, Marcos André Mendonça, Daniella Pereira Martins do Nascimento, Stefani Ingrid Barcelos, Pedro Marçal Correia de Lima, Rafaela Gomes da Costa, Kelli Monteiro Freire-de-Lima, Celio Geraldo Morrot, Alexandre Previato, Jose Osvaldo Mendonça Previato, Lucia da Fonseca, Leonardo Marques Freire-de-Lima, Leonardo Medicines (Basel) Opinion Cancer development and progression is associated with aberrant changes in cellular glycosylation. Cells expressing altered glycan-structures are recognized by cells of the immune system, favoring the induction of inhibitory immune processes which subsequently promote tumor growth and spreading. Here, we discuss about the importance of glycobiology in modern medicine, taking into account the impact of altered glycan structures expressed in cancer cells as potential glycobiomarkers of disease, as well as on cancer development and progression. MDPI 2022-05-24 /pmc/articles/PMC9229842/ /pubmed/35736247 http://dx.doi.org/10.3390/medicines9060034 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Opinion dos Reis, Jhenifer Santos Rodrigues da Costa Santos, Marcos André Mendonça, Daniella Pereira Martins do Nascimento, Stefani Ingrid Barcelos, Pedro Marçal Correia de Lima, Rafaela Gomes da Costa, Kelli Monteiro Freire-de-Lima, Celio Geraldo Morrot, Alexandre Previato, Jose Osvaldo Mendonça Previato, Lucia da Fonseca, Leonardo Marques Freire-de-Lima, Leonardo Glycobiology of Cancer: Sugar Drives the Show |
| title | Glycobiology of Cancer: Sugar Drives the Show |
| title_full | Glycobiology of Cancer: Sugar Drives the Show |
| title_fullStr | Glycobiology of Cancer: Sugar Drives the Show |
| title_full_unstemmed | Glycobiology of Cancer: Sugar Drives the Show |
| title_short | Glycobiology of Cancer: Sugar Drives the Show |
| title_sort | glycobiology of cancer: sugar drives the show |
| topic | Opinion |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229842/ https://www.ncbi.nlm.nih.gov/pubmed/35736247 http://dx.doi.org/10.3390/medicines9060034 |
| work_keys_str_mv | AT dosreisjhenifersantos glycobiologyofcancersugardrivestheshow AT rodriguesdacostasantosmarcosandre glycobiologyofcancersugardrivestheshow AT mendoncadaniellapereira glycobiologyofcancersugardrivestheshow AT martinsdonascimentostefaniingrid glycobiologyofcancersugardrivestheshow AT barcelospedromarcal glycobiologyofcancersugardrivestheshow AT correiadelimarafaelagomes glycobiologyofcancersugardrivestheshow AT dacostakellimonteiro glycobiologyofcancersugardrivestheshow AT freiredelimaceliogeraldo glycobiologyofcancersugardrivestheshow AT morrotalexandre glycobiologyofcancersugardrivestheshow AT previatojoseosvaldo glycobiologyofcancersugardrivestheshow AT mendoncapreviatolucia glycobiologyofcancersugardrivestheshow AT dafonsecaleonardomarques glycobiologyofcancersugardrivestheshow AT freiredelimaleonardo glycobiologyofcancersugardrivestheshow |