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Cancer-Related Somatic Mutations in Transmembrane Helices Alter Adenosine A1 Receptor Pharmacology

Overexpression of the adenosine A(1) receptor (A(1)AR) has been detected in various cancer cell lines. However, the role of A(1)AR in tumor development is still unclear. Thirteen A(1)AR mutations were identified in the Cancer Genome Atlas from cancer patient samples. We have investigated the pharmac...

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Detalles Bibliográficos
Autores principales:	Wang, Xuesong, Jespers, Willem, Wolff, Kim A. N., Buytelaar, Jill, IJzerman, Adriaan P., van Westen, Gerard J. P., Heitman, Laura H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229843/ https://www.ncbi.nlm.nih.gov/pubmed/35744872 http://dx.doi.org/10.3390/molecules27123742

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