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Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study

Existing literature on the association between influenza vaccination and COVID-19 infection/outcomes is conflicting. Therefore, we aimed to investigate the association between influenza vaccination and COVID-19 outcomes in a large cohort of adults who participated in the SHARE (Survey of Health, Age...

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Autores principales: Veronese, Nicola, Smith, Lee, Di Gennaro, Francesco, Bruyère, Olivier, Yang, Lin, Demurtas, Jacopo, Maggi, Stefania, Sabico, Shaun, Al-Daghri, Nasser M., Barbagallo, Mario, Dominguez, Ligia J., Koyanagi, Ai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229857/
https://www.ncbi.nlm.nih.gov/pubmed/35746506
http://dx.doi.org/10.3390/vaccines10060899
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author Veronese, Nicola
Smith, Lee
Di Gennaro, Francesco
Bruyère, Olivier
Yang, Lin
Demurtas, Jacopo
Maggi, Stefania
Sabico, Shaun
Al-Daghri, Nasser M.
Barbagallo, Mario
Dominguez, Ligia J.
Koyanagi, Ai
author_facet Veronese, Nicola
Smith, Lee
Di Gennaro, Francesco
Bruyère, Olivier
Yang, Lin
Demurtas, Jacopo
Maggi, Stefania
Sabico, Shaun
Al-Daghri, Nasser M.
Barbagallo, Mario
Dominguez, Ligia J.
Koyanagi, Ai
author_sort Veronese, Nicola
collection PubMed
description Existing literature on the association between influenza vaccination and COVID-19 infection/outcomes is conflicting. Therefore, we aimed to investigate the association between influenza vaccination and COVID-19 outcomes in a large cohort of adults who participated in the SHARE (Survey of Health, Ageing, and Retirement in Europe). Information regarding influenza vaccination in the previous year, and medical and demographic characteristics, were self-reported. Positivity for COVID-19, symptomatology, and hospitalization were also ascertained using self-reported information. An adjusted logistic regression analysis (including 15 baseline factors or propensity score) was used to assess the association between influenza vaccination and COVID-19 outcomes. A total of 48,408 participants (mean age 67 years; 54.1% females) were included. The prevalence of influenza vaccination was 38.3%. After adjusting for 15 potential confounders, influenza vaccination was significantly associated with a lower risk of positivity for COVID-19 (OR = 0.95; p < 0.0001), symptomatic forms (OR = 0.87; p < 0.0001), and hospitalization for COVID-19 (OR = 0.95; p < 0.0001). The results were similar when using a propensity score approach. In conclusion, influenza vaccination may be beneficial for the prevention of COVID-19, as the present study found that influenza vaccination was associated with a small/moderate lower risk of COVID-19 infection and adverse outcomes.
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spelling pubmed-92298572022-06-25 Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study Veronese, Nicola Smith, Lee Di Gennaro, Francesco Bruyère, Olivier Yang, Lin Demurtas, Jacopo Maggi, Stefania Sabico, Shaun Al-Daghri, Nasser M. Barbagallo, Mario Dominguez, Ligia J. Koyanagi, Ai Vaccines (Basel) Article Existing literature on the association between influenza vaccination and COVID-19 infection/outcomes is conflicting. Therefore, we aimed to investigate the association between influenza vaccination and COVID-19 outcomes in a large cohort of adults who participated in the SHARE (Survey of Health, Ageing, and Retirement in Europe). Information regarding influenza vaccination in the previous year, and medical and demographic characteristics, were self-reported. Positivity for COVID-19, symptomatology, and hospitalization were also ascertained using self-reported information. An adjusted logistic regression analysis (including 15 baseline factors or propensity score) was used to assess the association between influenza vaccination and COVID-19 outcomes. A total of 48,408 participants (mean age 67 years; 54.1% females) were included. The prevalence of influenza vaccination was 38.3%. After adjusting for 15 potential confounders, influenza vaccination was significantly associated with a lower risk of positivity for COVID-19 (OR = 0.95; p < 0.0001), symptomatic forms (OR = 0.87; p < 0.0001), and hospitalization for COVID-19 (OR = 0.95; p < 0.0001). The results were similar when using a propensity score approach. In conclusion, influenza vaccination may be beneficial for the prevention of COVID-19, as the present study found that influenza vaccination was associated with a small/moderate lower risk of COVID-19 infection and adverse outcomes. MDPI 2022-06-04 /pmc/articles/PMC9229857/ /pubmed/35746506 http://dx.doi.org/10.3390/vaccines10060899 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Veronese, Nicola
Smith, Lee
Di Gennaro, Francesco
Bruyère, Olivier
Yang, Lin
Demurtas, Jacopo
Maggi, Stefania
Sabico, Shaun
Al-Daghri, Nasser M.
Barbagallo, Mario
Dominguez, Ligia J.
Koyanagi, Ai
Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study
title Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study
title_full Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study
title_fullStr Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study
title_full_unstemmed Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study
title_short Influenza Vaccination and COVID-19 Outcomes in People Older than 50 Years: Data from the Observational Longitudinal SHARE Study
title_sort influenza vaccination and covid-19 outcomes in people older than 50 years: data from the observational longitudinal share study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229857/
https://www.ncbi.nlm.nih.gov/pubmed/35746506
http://dx.doi.org/10.3390/vaccines10060899
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