Cargando…

A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute

BACKGROUND: According to the World Health Organization about 2.6 million deaths were reported worldwide in 2015. More than 98% of stillbirths occur in developing countries. At present, the causes of many cases of stillbirth are unknown due to the lack of necessary data and autopsies in Iran. The aim...

Descripción completa

Detalles Bibliográficos
Autores principales: Soltanghoraee, Haleh, Moradi-Lakeh, Maziar, Khalili, Narjes, Soltani, Azadeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229882/
https://www.ncbi.nlm.nih.gov/pubmed/35739463
http://dx.doi.org/10.1186/s12884-022-04822-9
_version_ 1784734882548678656
author Soltanghoraee, Haleh
Moradi-Lakeh, Maziar
Khalili, Narjes
Soltani, Azadeh
author_facet Soltanghoraee, Haleh
Moradi-Lakeh, Maziar
Khalili, Narjes
Soltani, Azadeh
author_sort Soltanghoraee, Haleh
collection PubMed
description BACKGROUND: According to the World Health Organization about 2.6 million deaths were reported worldwide in 2015. More than 98% of stillbirths occur in developing countries. At present, the causes of many cases of stillbirth are unknown due to the lack of necessary data and autopsies in Iran. The aim of this study was to investigate the most plausible cause of stillbirth by evaluating clinical records and autopsies. METHODS: A cross-sectional study of 42 stillbirth autopsies in Avicenna Research Institute from 2012 to 2019, was conducted. Data were extracted from a checklist prepared by the project researchers. The checklist contains maternal demographic information, medical history and maternal illness, pregnancy risk factors, placenta and stillbirth information. Collected data were reviewed and classified according to the ReCoDe (Relevant Condition at Death) system. RESULTS: In the present study, based on ReCoDe classification, related causes of 95.2% of stillbirths were identified and 4.8% were in the unclassified group. The most common causes were: Fetal causes (64.3%), umbilical cord (14.3%), placenta (7.1%), amniotic fluid (4.8%), maternal medical conditions (2.4%). The causes of about 70% of stillbirth in Iran are unexplained, but in this study, using autopsy results and ReCoDe classification, only 4.8% of stillbirth causes remained unexplained. CONCLUSIONS: In our study, unknown cases were rare after autopsy. But considering the limitations and costs of autopsy, we need to design the guideline to specify cases who need an autopsy. Fetal autopsy, placental examination and clinical information could reduce the proportion of stillbirths that remain unexplained. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-022-04822-9.
format Online
Article
Text
id pubmed-9229882
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-92298822022-06-25 A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute Soltanghoraee, Haleh Moradi-Lakeh, Maziar Khalili, Narjes Soltani, Azadeh BMC Pregnancy Childbirth Research BACKGROUND: According to the World Health Organization about 2.6 million deaths were reported worldwide in 2015. More than 98% of stillbirths occur in developing countries. At present, the causes of many cases of stillbirth are unknown due to the lack of necessary data and autopsies in Iran. The aim of this study was to investigate the most plausible cause of stillbirth by evaluating clinical records and autopsies. METHODS: A cross-sectional study of 42 stillbirth autopsies in Avicenna Research Institute from 2012 to 2019, was conducted. Data were extracted from a checklist prepared by the project researchers. The checklist contains maternal demographic information, medical history and maternal illness, pregnancy risk factors, placenta and stillbirth information. Collected data were reviewed and classified according to the ReCoDe (Relevant Condition at Death) system. RESULTS: In the present study, based on ReCoDe classification, related causes of 95.2% of stillbirths were identified and 4.8% were in the unclassified group. The most common causes were: Fetal causes (64.3%), umbilical cord (14.3%), placenta (7.1%), amniotic fluid (4.8%), maternal medical conditions (2.4%). The causes of about 70% of stillbirth in Iran are unexplained, but in this study, using autopsy results and ReCoDe classification, only 4.8% of stillbirth causes remained unexplained. CONCLUSIONS: In our study, unknown cases were rare after autopsy. But considering the limitations and costs of autopsy, we need to design the guideline to specify cases who need an autopsy. Fetal autopsy, placental examination and clinical information could reduce the proportion of stillbirths that remain unexplained. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12884-022-04822-9. BioMed Central 2022-06-23 /pmc/articles/PMC9229882/ /pubmed/35739463 http://dx.doi.org/10.1186/s12884-022-04822-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Soltanghoraee, Haleh
Moradi-Lakeh, Maziar
Khalili, Narjes
Soltani, Azadeh
A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute
title A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute
title_full A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute
title_fullStr A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute
title_full_unstemmed A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute
title_short A retrospective autopsy study of 42 cases of stillbirth in Avicenna Research Institute
title_sort retrospective autopsy study of 42 cases of stillbirth in avicenna research institute
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229882/
https://www.ncbi.nlm.nih.gov/pubmed/35739463
http://dx.doi.org/10.1186/s12884-022-04822-9
work_keys_str_mv AT soltanghoraeehaleh aretrospectiveautopsystudyof42casesofstillbirthinavicennaresearchinstitute
AT moradilakehmaziar aretrospectiveautopsystudyof42casesofstillbirthinavicennaresearchinstitute
AT khalilinarjes aretrospectiveautopsystudyof42casesofstillbirthinavicennaresearchinstitute
AT soltaniazadeh aretrospectiveautopsystudyof42casesofstillbirthinavicennaresearchinstitute
AT soltanghoraeehaleh retrospectiveautopsystudyof42casesofstillbirthinavicennaresearchinstitute
AT moradilakehmaziar retrospectiveautopsystudyof42casesofstillbirthinavicennaresearchinstitute
AT khalilinarjes retrospectiveautopsystudyof42casesofstillbirthinavicennaresearchinstitute
AT soltaniazadeh retrospectiveautopsystudyof42casesofstillbirthinavicennaresearchinstitute