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A Hybrid of Amodiaquine and Primaquine Linked by Gold(I) Is a Multistage Antimalarial Agent Targeting Heme Detoxification and Thiol Redox Homeostasis

Hybrid-based drugs linked through a transition metal constitute an emerging concept for Plasmodium intervention. To advance the drug design concept and enhance the therapeutic potential of this class of drugs, we developed a novel hybrid composed of quinolinic ligands amodiaquine (AQ) and primaquine...

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Detalles Bibliográficos
Autores principales:	De Souza Pereira, Caroline, Quadros, Helenita Costa, Aboagye, Samuel Yaw, Fontinha, Diana, D’Alessandro, Sarah, Byrne, Margaret Elizabeth, Gendrot, Mathieu, Fonta, Isabelle, Mosnier, Joel, Moreira, Diogo Rodrigo M., Basilico, Nicoletta, Williams, David L., Prudêncio, Miguel, Pradines, Bruno, Navarro, Maribel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229949/ https://www.ncbi.nlm.nih.gov/pubmed/35745823 http://dx.doi.org/10.3390/pharmaceutics14061251

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