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Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs
Nowadays, the most commonly used fixation systems are non-resorbable, but new resorbable magnesium alloy fixation screws have been introduced recently. Therefore, the aim of this study was to compare the magnesium fixation screw and the commonly used non-resorbable titanium screw in an animal model....
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229971/ https://www.ncbi.nlm.nih.gov/pubmed/35744169 http://dx.doi.org/10.3390/ma15124111 |
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author | Rider, Patrick Kačarević, Željka Perić Elad, Akiva Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Molnar, Balint Hesse, Bernhard Assad, Michel Witte, Frank |
author_facet | Rider, Patrick Kačarević, Željka Perić Elad, Akiva Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Molnar, Balint Hesse, Bernhard Assad, Michel Witte, Frank |
author_sort | Rider, Patrick |
collection | PubMed |
description | Nowadays, the most commonly used fixation systems are non-resorbable, but new resorbable magnesium alloy fixation screws have been introduced recently. Therefore, the aim of this study was to compare the magnesium fixation screw and the commonly used non-resorbable titanium screw in an animal model. Four 3-wall defect sites were covered with collagen membranes in the mandible of twenty beagle dogs (two sites on the left and two on the right). Each membrane was fixed with either four magnesium screws or four titanium screws. Post-operative follow-up revealed the expected observations such as transient inflammation and pain. Both groups showed a good healing response, with no differences between groups. Micro-CT analysis showed no significant difference between groups in terms of BV/TV or soft tissue volume. The void volume in the magnesium fixation screw group continued to decrease on average between the different timepoints, but not significantly. Furthermore, a gradual progression of the degradation process of the magnesium screws was observed in the same group. Magnesium screws and titanium screws showed equal performance in tissue regeneration according to GBR principles. An additional advantage of magnesium screws is their resorbable nature, which eliminates the need for a second surgical step to remove the screws. |
format | Online Article Text |
id | pubmed-9229971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92299712022-06-25 Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs Rider, Patrick Kačarević, Željka Perić Elad, Akiva Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Molnar, Balint Hesse, Bernhard Assad, Michel Witte, Frank Materials (Basel) Article Nowadays, the most commonly used fixation systems are non-resorbable, but new resorbable magnesium alloy fixation screws have been introduced recently. Therefore, the aim of this study was to compare the magnesium fixation screw and the commonly used non-resorbable titanium screw in an animal model. Four 3-wall defect sites were covered with collagen membranes in the mandible of twenty beagle dogs (two sites on the left and two on the right). Each membrane was fixed with either four magnesium screws or four titanium screws. Post-operative follow-up revealed the expected observations such as transient inflammation and pain. Both groups showed a good healing response, with no differences between groups. Micro-CT analysis showed no significant difference between groups in terms of BV/TV or soft tissue volume. The void volume in the magnesium fixation screw group continued to decrease on average between the different timepoints, but not significantly. Furthermore, a gradual progression of the degradation process of the magnesium screws was observed in the same group. Magnesium screws and titanium screws showed equal performance in tissue regeneration according to GBR principles. An additional advantage of magnesium screws is their resorbable nature, which eliminates the need for a second surgical step to remove the screws. MDPI 2022-06-09 /pmc/articles/PMC9229971/ /pubmed/35744169 http://dx.doi.org/10.3390/ma15124111 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rider, Patrick Kačarević, Željka Perić Elad, Akiva Rothamel, Daniel Sauer, Gerrit Bornert, Fabien Windisch, Peter Hangyási, Dávid Molnar, Balint Hesse, Bernhard Assad, Michel Witte, Frank Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs |
title | Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs |
title_full | Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs |
title_fullStr | Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs |
title_full_unstemmed | Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs |
title_short | Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs |
title_sort | biodegradation of a magnesium alloy fixation screw used in a guided bone regeneration model in beagle dogs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229971/ https://www.ncbi.nlm.nih.gov/pubmed/35744169 http://dx.doi.org/10.3390/ma15124111 |
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