mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis

Regulatory T cells (T(regs)) have shown great promise as a means of cellular therapy in a multitude of allo- and auto-immune diseases—due in part to their immunosuppressive potency. Nevertheless, the clinical efficacy of human T(regs) in patients has been limited by their poor in vivo homeostasis. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Eskandari, Siawosh K., Allos, Hazim, Al Dulaijan, Basmah S., Melhem, Gandolina, Sulkaj, Ina, Alhaddad, Juliano B., Saad, Anis J., Deban, Christa, Chu, Philip, Choi, John Y., Kollar, Branislav, Pomahac, Bohdan, Riella, Leonardo V., Berger, Stefan P., Sanders, Jan S. F., Lieberman, Judy, Li, Li, Azzi, Jamil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229986/
https://www.ncbi.nlm.nih.gov/pubmed/35757726
http://dx.doi.org/10.3389/fimmu.2022.899975

Ejemplares similares

Ejemplares similares