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The Intervention of Prebiotics on Depression via the Gut–Brain Axis
The imbalance of intestinal microbiota can cause the accumulation of endotoxin in the main circulation system of the human body, which has a great impact on human health. Increased work and life pressure have led to a rise in the number of people falling into depression, which has also reduced their...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230023/ https://www.ncbi.nlm.nih.gov/pubmed/35744797 http://dx.doi.org/10.3390/molecules27123671 |
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author | He, Qinghui Si, Congcong Sun, Zhenjiao Chen, Yuhui Zhang, Xin |
author_facet | He, Qinghui Si, Congcong Sun, Zhenjiao Chen, Yuhui Zhang, Xin |
author_sort | He, Qinghui |
collection | PubMed |
description | The imbalance of intestinal microbiota can cause the accumulation of endotoxin in the main circulation system of the human body, which has a great impact on human health. Increased work and life pressure have led to a rise in the number of people falling into depression, which has also reduced their quality of life. The gut–brain axis (GBA) is closely related to the pathological basis of depression, and intestinal microbiota can improve depressive symptoms through GBA. Previous studies have proven that prebiotics can modulate intestinal microbiota and thus participate in human health regulation. We reviewed the regulatory mechanism of intestinal microbiota on depression through GBA, and discussed the effects of prebiotics, including plant polysaccharides and polyphenols on the regulation of intestinal microbiota, providing new clues for the prevention and treatment of depression. |
format | Online Article Text |
id | pubmed-9230023 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92300232022-06-25 The Intervention of Prebiotics on Depression via the Gut–Brain Axis He, Qinghui Si, Congcong Sun, Zhenjiao Chen, Yuhui Zhang, Xin Molecules Review The imbalance of intestinal microbiota can cause the accumulation of endotoxin in the main circulation system of the human body, which has a great impact on human health. Increased work and life pressure have led to a rise in the number of people falling into depression, which has also reduced their quality of life. The gut–brain axis (GBA) is closely related to the pathological basis of depression, and intestinal microbiota can improve depressive symptoms through GBA. Previous studies have proven that prebiotics can modulate intestinal microbiota and thus participate in human health regulation. We reviewed the regulatory mechanism of intestinal microbiota on depression through GBA, and discussed the effects of prebiotics, including plant polysaccharides and polyphenols on the regulation of intestinal microbiota, providing new clues for the prevention and treatment of depression. MDPI 2022-06-07 /pmc/articles/PMC9230023/ /pubmed/35744797 http://dx.doi.org/10.3390/molecules27123671 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review He, Qinghui Si, Congcong Sun, Zhenjiao Chen, Yuhui Zhang, Xin The Intervention of Prebiotics on Depression via the Gut–Brain Axis |
title | The Intervention of Prebiotics on Depression via the Gut–Brain Axis |
title_full | The Intervention of Prebiotics on Depression via the Gut–Brain Axis |
title_fullStr | The Intervention of Prebiotics on Depression via the Gut–Brain Axis |
title_full_unstemmed | The Intervention of Prebiotics on Depression via the Gut–Brain Axis |
title_short | The Intervention of Prebiotics on Depression via the Gut–Brain Axis |
title_sort | intervention of prebiotics on depression via the gut–brain axis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230023/ https://www.ncbi.nlm.nih.gov/pubmed/35744797 http://dx.doi.org/10.3390/molecules27123671 |
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