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Ocular Adverse Events after Inactivated COVID-19 Vaccination
Purpose: To report the clinical characteristics of ocular adverse events that have occurred, in China, after vaccination with inactivated COVID-19 vaccines. Methods: A retrospective cross-sectional observational study was conducted of ocular disorders that occurred within 15 days from any dose of an...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230105/ https://www.ncbi.nlm.nih.gov/pubmed/35746527 http://dx.doi.org/10.3390/vaccines10060918 |
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author | Li, Zhihua Hu, Feng Li, Qian Wang, Shuang Chen, Chunli Zhang, Yongpeng Mao, Yu Shi, Xuehui Zhou, Haiying Cao, Xusheng Peng, Xiaoyan |
author_facet | Li, Zhihua Hu, Feng Li, Qian Wang, Shuang Chen, Chunli Zhang, Yongpeng Mao, Yu Shi, Xuehui Zhou, Haiying Cao, Xusheng Peng, Xiaoyan |
author_sort | Li, Zhihua |
collection | PubMed |
description | Purpose: To report the clinical characteristics of ocular adverse events that have occurred, in China, after vaccination with inactivated COVID-19 vaccines. Methods: A retrospective cross-sectional observational study was conducted of ocular disorders that occurred within 15 days from any dose of an inactivated COVID-19 vaccine. Information on gender, age, the interval between the vaccination and ocular symptoms, laterality, duration of the ocular symptoms, primary visual acuity, and clinical diagnosis were retrospectively collected. Results: Twenty-four patients were involved in the study, including 15 females and 9 males, with a mean age of 41 ± 16 years (range of 8–71 years). The patients all denied a prior history of COVID-19 infection. Ocular adverse events occurred after the first dose of vaccine in 18 patients and, after the second or third doses, in six patients. The interval between vaccination with the inactivated COVID-19 vaccine and ocular symptoms was 6 ± 5 days; six patients were bilaterally involved and 18 patients were unilaterally involved. Regarding the diagnosis, 10 patients were diagnosed with white dot syndrome (WDS), 9 patients were diagnosed with uveitis, and 5 patients were diagnosed with retinal vascular disorders. The ages of patients with WDS were younger than those with uveitis or retinal vascular disorders (32 ± 10 vs. 48 ± 18, p < 0.05). For patients diagnosed with WDS, the best-corrected visual acuity (BCVA) was 0.74 ± 0.73 LogMAR. For patients diagnosed with retinal vascular disorders or uveitis, the BCVA was 1.44 ± 1.26 LogMAR. There was no significant difference (p > 0.05). Conclusions: A relationship cannot be established between inactivated COVID-19 vaccines and ocular disorders; therefore, further investigation of the clinical spectrum of ocular adverse events after vaccination with an inactivated COVID-19 vaccine is necessary. |
format | Online Article Text |
id | pubmed-9230105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92301052022-06-25 Ocular Adverse Events after Inactivated COVID-19 Vaccination Li, Zhihua Hu, Feng Li, Qian Wang, Shuang Chen, Chunli Zhang, Yongpeng Mao, Yu Shi, Xuehui Zhou, Haiying Cao, Xusheng Peng, Xiaoyan Vaccines (Basel) Article Purpose: To report the clinical characteristics of ocular adverse events that have occurred, in China, after vaccination with inactivated COVID-19 vaccines. Methods: A retrospective cross-sectional observational study was conducted of ocular disorders that occurred within 15 days from any dose of an inactivated COVID-19 vaccine. Information on gender, age, the interval between the vaccination and ocular symptoms, laterality, duration of the ocular symptoms, primary visual acuity, and clinical diagnosis were retrospectively collected. Results: Twenty-four patients were involved in the study, including 15 females and 9 males, with a mean age of 41 ± 16 years (range of 8–71 years). The patients all denied a prior history of COVID-19 infection. Ocular adverse events occurred after the first dose of vaccine in 18 patients and, after the second or third doses, in six patients. The interval between vaccination with the inactivated COVID-19 vaccine and ocular symptoms was 6 ± 5 days; six patients were bilaterally involved and 18 patients were unilaterally involved. Regarding the diagnosis, 10 patients were diagnosed with white dot syndrome (WDS), 9 patients were diagnosed with uveitis, and 5 patients were diagnosed with retinal vascular disorders. The ages of patients with WDS were younger than those with uveitis or retinal vascular disorders (32 ± 10 vs. 48 ± 18, p < 0.05). For patients diagnosed with WDS, the best-corrected visual acuity (BCVA) was 0.74 ± 0.73 LogMAR. For patients diagnosed with retinal vascular disorders or uveitis, the BCVA was 1.44 ± 1.26 LogMAR. There was no significant difference (p > 0.05). Conclusions: A relationship cannot be established between inactivated COVID-19 vaccines and ocular disorders; therefore, further investigation of the clinical spectrum of ocular adverse events after vaccination with an inactivated COVID-19 vaccine is necessary. MDPI 2022-06-09 /pmc/articles/PMC9230105/ /pubmed/35746527 http://dx.doi.org/10.3390/vaccines10060918 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Zhihua Hu, Feng Li, Qian Wang, Shuang Chen, Chunli Zhang, Yongpeng Mao, Yu Shi, Xuehui Zhou, Haiying Cao, Xusheng Peng, Xiaoyan Ocular Adverse Events after Inactivated COVID-19 Vaccination |
title | Ocular Adverse Events after Inactivated COVID-19 Vaccination |
title_full | Ocular Adverse Events after Inactivated COVID-19 Vaccination |
title_fullStr | Ocular Adverse Events after Inactivated COVID-19 Vaccination |
title_full_unstemmed | Ocular Adverse Events after Inactivated COVID-19 Vaccination |
title_short | Ocular Adverse Events after Inactivated COVID-19 Vaccination |
title_sort | ocular adverse events after inactivated covid-19 vaccination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230105/ https://www.ncbi.nlm.nih.gov/pubmed/35746527 http://dx.doi.org/10.3390/vaccines10060918 |
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