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Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis

This study aimed to investigate whether a combined estimation of the geriatric nutritional risk index (GNRI) and the modified creatinine index (mCI) provides synergistic information for mortality in patients treated by chronic hemodialysis. We analyzed 499 patients on hemodialysis for five years. We...

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Autores principales: Naito, Takayuki, Doi, Toshiki, Morii, Kenichi, Usui, Koji, Arita, Michiko, Yamashita, Kazuomi, Shigemoto, Kenichiro, Nishizawa, Yoshiko, Mizuiri, Sonoo, Sasaki, Kensuke, Masaki, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230177/
https://www.ncbi.nlm.nih.gov/pubmed/35745130
http://dx.doi.org/10.3390/nu14122398
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author Naito, Takayuki
Doi, Toshiki
Morii, Kenichi
Usui, Koji
Arita, Michiko
Yamashita, Kazuomi
Shigemoto, Kenichiro
Nishizawa, Yoshiko
Mizuiri, Sonoo
Sasaki, Kensuke
Masaki, Takao
author_facet Naito, Takayuki
Doi, Toshiki
Morii, Kenichi
Usui, Koji
Arita, Michiko
Yamashita, Kazuomi
Shigemoto, Kenichiro
Nishizawa, Yoshiko
Mizuiri, Sonoo
Sasaki, Kensuke
Masaki, Takao
author_sort Naito, Takayuki
collection PubMed
description This study aimed to investigate whether a combined estimation of the geriatric nutritional risk index (GNRI) and the modified creatinine index (mCI) provides synergistic information for mortality in patients treated by chronic hemodialysis. We analyzed 499 patients on hemodialysis for five years. We set each cut-off value as the high (≥92) and low (<92) GNRI groups and the high (≥21 mg/kg/day) and low (<21 mg/kg/day) mCI groups, and divided them into four subgroups: G1, high GNRI + high mCI; G2, high GNRI + low mCI; G3, low GNRI + high mCI; and G4, low GNRI + low mCI. The survival rate was evaluated and time-to-event analysis was performed. All-cause death occurred in 142 (28%) patients. Kaplan–Meier curves showed that G2 and G4 had a significantly worse outcome (p < 0.05) than G1 but not G3. Using the multivariable-adjusted model, only G4 was significantly associated with all-cause mortality compared with G1. Our study suggests that the synergistic effects of the GNRI and the mCI are helpful in predicting all-cause mortality. The combination of these indices may be superior to a single method to distinguish patients who are well or moderately ill from potentially severely ill.
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spelling pubmed-92301772022-06-25 Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis Naito, Takayuki Doi, Toshiki Morii, Kenichi Usui, Koji Arita, Michiko Yamashita, Kazuomi Shigemoto, Kenichiro Nishizawa, Yoshiko Mizuiri, Sonoo Sasaki, Kensuke Masaki, Takao Nutrients Article This study aimed to investigate whether a combined estimation of the geriatric nutritional risk index (GNRI) and the modified creatinine index (mCI) provides synergistic information for mortality in patients treated by chronic hemodialysis. We analyzed 499 patients on hemodialysis for five years. We set each cut-off value as the high (≥92) and low (<92) GNRI groups and the high (≥21 mg/kg/day) and low (<21 mg/kg/day) mCI groups, and divided them into four subgroups: G1, high GNRI + high mCI; G2, high GNRI + low mCI; G3, low GNRI + high mCI; and G4, low GNRI + low mCI. The survival rate was evaluated and time-to-event analysis was performed. All-cause death occurred in 142 (28%) patients. Kaplan–Meier curves showed that G2 and G4 had a significantly worse outcome (p < 0.05) than G1 but not G3. Using the multivariable-adjusted model, only G4 was significantly associated with all-cause mortality compared with G1. Our study suggests that the synergistic effects of the GNRI and the mCI are helpful in predicting all-cause mortality. The combination of these indices may be superior to a single method to distinguish patients who are well or moderately ill from potentially severely ill. MDPI 2022-06-09 /pmc/articles/PMC9230177/ /pubmed/35745130 http://dx.doi.org/10.3390/nu14122398 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Naito, Takayuki
Doi, Toshiki
Morii, Kenichi
Usui, Koji
Arita, Michiko
Yamashita, Kazuomi
Shigemoto, Kenichiro
Nishizawa, Yoshiko
Mizuiri, Sonoo
Sasaki, Kensuke
Masaki, Takao
Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis
title Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis
title_full Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis
title_fullStr Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis
title_full_unstemmed Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis
title_short Synergistic Effects of the Geriatric Nutritional Risk Index and the Modified Creatinine Index for Predicting Mortality in Patients on Hemodialysis
title_sort synergistic effects of the geriatric nutritional risk index and the modified creatinine index for predicting mortality in patients on hemodialysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230177/
https://www.ncbi.nlm.nih.gov/pubmed/35745130
http://dx.doi.org/10.3390/nu14122398
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