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A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan

Purpose: Several studies have shown that polypharmacy is the main cause of drug interactions, and the prevalence and the level of the severity varied with the duration of stay in the hospital, sex and race of the patients. The aims of this investigation were to identify the drug-drug interactions in...

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Autores principales: Nawaz, Hafiz Awais, Khan, Tahir Mehmood, Adil, Qendeel, Goh, Khang Wen, Ming, Long Chiau, Blebil, Ali Qais, Lee, Kah Seng, Dhaliwal, Jagjit Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230244/
https://www.ncbi.nlm.nih.gov/pubmed/35736660
http://dx.doi.org/10.3390/pediatric14020038
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author Nawaz, Hafiz Awais
Khan, Tahir Mehmood
Adil, Qendeel
Goh, Khang Wen
Ming, Long Chiau
Blebil, Ali Qais
Lee, Kah Seng
Dhaliwal, Jagjit Singh
author_facet Nawaz, Hafiz Awais
Khan, Tahir Mehmood
Adil, Qendeel
Goh, Khang Wen
Ming, Long Chiau
Blebil, Ali Qais
Lee, Kah Seng
Dhaliwal, Jagjit Singh
author_sort Nawaz, Hafiz Awais
collection PubMed
description Purpose: Several studies have shown that polypharmacy is the main cause of drug interactions, and the prevalence and the level of the severity varied with the duration of stay in the hospital, sex and race of the patients. The aims of this investigation were to identify the drug-drug interactions in hospitalized pediatric patients associated with polypharmacy, and to categorize the drug interactions in pharmacokinetic or pharmacodynamic interactions according to their level of severity. Methods: A cross-sectional, prospective analytical study was performed at a pediatric tertiary care hospital in Lahore, Pakistan for the duration of 4 months, which included prescription orders for 300 patients. Data were collected from patient medical files about previous and current medication history. Drug interactions were analyzed using interaction checker on Medscape and categorized according to the severity levels. Results: Out of 300 patients, the occurrence of drug interactions was found in 157 (52.3%) patients, while in 143 (47.7%), no interaction was found. Among these interactions, 50.7% were pharmacodynamic interactions, and 49.30% were pharmacokinetic interactions. Eighty-one percent of prescription orders with drug interactions contained more than three drugs, and 11.9% of interactions were severe. The majority of interactions were of amikacin-vancomycin, piroxicam-captopril and captopril-ciprofloxacin. Conclusion: Most of the interactions were moderate among patients with multiple drug prescriptions. The drug interactions can be minimized by providing special patient monitoring and adequate management with prior knowledge of these drug interaction.
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spelling pubmed-92302442022-06-25 A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan Nawaz, Hafiz Awais Khan, Tahir Mehmood Adil, Qendeel Goh, Khang Wen Ming, Long Chiau Blebil, Ali Qais Lee, Kah Seng Dhaliwal, Jagjit Singh Pediatr Rep Article Purpose: Several studies have shown that polypharmacy is the main cause of drug interactions, and the prevalence and the level of the severity varied with the duration of stay in the hospital, sex and race of the patients. The aims of this investigation were to identify the drug-drug interactions in hospitalized pediatric patients associated with polypharmacy, and to categorize the drug interactions in pharmacokinetic or pharmacodynamic interactions according to their level of severity. Methods: A cross-sectional, prospective analytical study was performed at a pediatric tertiary care hospital in Lahore, Pakistan for the duration of 4 months, which included prescription orders for 300 patients. Data were collected from patient medical files about previous and current medication history. Drug interactions were analyzed using interaction checker on Medscape and categorized according to the severity levels. Results: Out of 300 patients, the occurrence of drug interactions was found in 157 (52.3%) patients, while in 143 (47.7%), no interaction was found. Among these interactions, 50.7% were pharmacodynamic interactions, and 49.30% were pharmacokinetic interactions. Eighty-one percent of prescription orders with drug interactions contained more than three drugs, and 11.9% of interactions were severe. The majority of interactions were of amikacin-vancomycin, piroxicam-captopril and captopril-ciprofloxacin. Conclusion: Most of the interactions were moderate among patients with multiple drug prescriptions. The drug interactions can be minimized by providing special patient monitoring and adequate management with prior knowledge of these drug interaction. MDPI 2022-06-15 /pmc/articles/PMC9230244/ /pubmed/35736660 http://dx.doi.org/10.3390/pediatric14020038 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nawaz, Hafiz Awais
Khan, Tahir Mehmood
Adil, Qendeel
Goh, Khang Wen
Ming, Long Chiau
Blebil, Ali Qais
Lee, Kah Seng
Dhaliwal, Jagjit Singh
A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan
title A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan
title_full A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan
title_fullStr A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan
title_full_unstemmed A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan
title_short A Prospective Study of Medication Surveillance of a Pediatric Tertiary Care Hospital in Lahore, Pakistan
title_sort prospective study of medication surveillance of a pediatric tertiary care hospital in lahore, pakistan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230244/
https://www.ncbi.nlm.nih.gov/pubmed/35736660
http://dx.doi.org/10.3390/pediatric14020038
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