Cargando…

HDAC Inhibitors for the Therapy of Triple Negative Breast Cancer

Triple negative breast cancer (TNBC) is an urgent as well as huge medical challenge, which is associated with poor prognosis and responsiveness to chemotherapies. Since epigenetic changes are highly implicated in TNBC tumorigenesis and development, inhibitors of histone deacetylases (HDACIs) could r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maccallini, Cristina, Ammazzalorso, Alessandra, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Amoroso, Rosa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230362/ https://www.ncbi.nlm.nih.gov/pubmed/35745586 http://dx.doi.org/10.3390/ph15060667

Ejemplares similares

The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro
por: Gallorini, Marialucia, et al.
Publicado: (2019)

New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study
por: Maccallini, Cristina, et al.
Publicado: (2021)

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies
por: Ammazzalorso, Alessandra, et al.
Publicado: (2019)

Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol
por: Fantacuzzi, Marialuigia, et al.
Publicado: (2021)

Benzothiazole Derivatives Endowed with Antiproliferative Activity in Paraganglioma and Pancreatic Cancer Cells: Structure–Activity Relationship Studies and Target Prediction Analysis
por: Amoroso, Rosa, et al.
Publicado: (2022)

Development of CDK4/6 Inhibitors: A Five Years Update
por: Ammazzalorso, Alessandra, et al.
Publicado: (2021)

PPAR Ligands Induce Antiviral Effects Targeting Perturbed Lipid Metabolism during SARS-CoV-2, HCV, and HCMV Infection
por: Fantacuzzi, Marialuigia, et al.
Publicado: (2022)

Anticancer Inhibitors
por: Ammazzalorso, Alessandra, et al.
Publicado: (2022)

Anticancer Activity of Natural Products and Related Compounds
por: De Filippis, Barbara, et al.
Publicado: (2023)

Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
por: Ammazzalorso, Alessandra, et al.
Publicado: (2020)

A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential
por: Maccallini, Cristina, et al.
Publicado: (2020)

Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?
por: Carradori, Simone, et al.
Publicado: (2022)

Development of a Rapid Mass Spectrometric Determination of AMP and Cyclic AMP for PDE3 Activity Study: Application and Computational Analysis for Evaluating the Effect of a Novel 2-oxo-1,2-dihydropyridine-3-carbonitrile Derivative as PDE-3 Inhibitor
por: Cicalini, Ilaria, et al.
Publicado: (2020)

Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies
por: Ammazzalorso, Alessandra, et al.
Publicado: (2016)

LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer
por: Li, Mengxing, et al.
Publicado: (2021)

Targeting neuronal nitric oxide synthase as a valuable strategy for the therapy of neurological disorders
por: Maccallini, Cristina, et al.
Publicado: (2016)

HDAC inhibition potentiates immunotherapy in triple negative breast cancer
por: Terranova-Barberio, Manuela, et al.
Publicado: (2017)

HDAC6 inhibitors sensitize non-mesenchymal triple-negative breast cancer cells to cysteine deprivation
por: Alothaim, Tahiyat, et al.
Publicado: (2021)

Association of HDAC8 Expression with Pathological Findings in Triple Negative and Non-Triple Negative Breast Cancer: Implications for Diagnosis
por: Menbari, Mohammad-Nazir, et al.
Publicado: (2020)

Preface to Nitric Oxide Modulators in Health and Disease I
por: Maccallini, Cristina, et al.
Publicado: (2022)

Neuronal Nitric Oxide Synthase and Post-Translational Modifications in the Development of Central Nervous System Diseases: Implications and Regulation
por: Maccallini, Cristina, et al.
Publicado: (2023)

Anti-Inflammatory, Antioxidant, and WAT/BAT-Conversion Stimulation Induced by Novel PPAR Ligands: Results from Ex Vivo and In Vitro Studies
por: Recinella, Lucia, et al.
Publicado: (2023)

Checkpoint inhibitor therapy for metastatic triple-negative breast cancer
por: Heeke, Arielle L., et al.
Publicado: (2021)

Cell-of-Origin Targeted Drug Repurposing for Triple-Negative and Inflammatory Breast Carcinoma with HDAC and HSP90 Inhibitors Combined with Niclosamide
por: Bhattacharya, Udayan, et al.
Publicado: (2023)

Choline Chloride-Based DES as Solvents/Catalysts/Chemical Donors in Pharmaceutical Synthesis
por: Amoroso, Rosa, et al.
Publicado: (2021)

Activators of Nrf2 to Counteract Neurodegenerative Diseases
por: Amoroso, Rosa, et al.
Publicado: (2023)

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold
por: Rotondi, Giulia, et al.
Publicado: (2019)

Selective Inhibitors of the Inducible Nitric Oxide Synthase as Modulators of Cell Responses in LPS-Stimulated Human Monocytes
por: Gallorini, Marialucia, et al.
Publicado: (2021)

CXCL1 Clone Evolution Induced by the HDAC Inhibitor Belinostat Might Be a Favorable Prognostic Indicator in Triple-Negative Breast Cancer
por: Han, Xin-le, et al.
Publicado: (2021)

HDAC Inhibitors Enhance Efficacy of the Oncolytic Adenoviruses Ad∆∆ and Ad-3∆-A20T in Pancreatic and Triple-Negative Breast Cancer Models
por: Rodríguez, María Del Carmen Rodríguez, et al.
Publicado: (2022)

Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer
por: Dowling, Catríona M., et al.
Publicado: (2021)

Triple-negative breast cancer and radiation therapy
por: de Faria Bessa, Jordana, et al.
Publicado: (2022)

Acetamidine-Based iNOS Inhibitors as Molecular Tools to Counteract Inflammation in BV2 Microglial Cells
por: Grottelli, Silvia, et al.
Publicado: (2020)

Coumarin-Based Dual Inhibitors of Human Carbonic Anhydrases and Monoamine Oxidases Featuring Amino Acyl and (Pseudo)-Dipeptidyl Appendages: In Vitro and Computational Studies
por: Agamennone, Mariangela, et al.
Publicado: (2022)

Role of BET Inhibitors in Triple Negative Breast Cancers
por: Khandekar, Durga, et al.
Publicado: (2020)

Phenylsulfonimide PPARα Antagonists Enhance Nrf2 Activation and Promote Oxidative Stress-Induced Apoptosis/Pyroptosis in MCF7 Breast Cancer Cells
por: Gallorini, Marialucia, et al.
Publicado: (2023)

HDAC7 inhibits cell proliferation via NudCD1/GGH axis in triple-negative breast cancer
por: Zhu, Mengdi, et al.
Publicado: (2022)

Immune-Based Therapy in Triple-Negative Breast Cancer: From Molecular Biology to Clinical Practice
por: Carlino, Francesca, et al.
Publicado: (2022)

Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer
por: Dias, Cristina J., et al.
Publicado: (2021)

Translating the role of PARP inhibitors in triple-negative breast cancer
por: Beniey, Michèle, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tsj5pf59bc2ngic6r2hge6mf23