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Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions

A non-enzymatic electrochemical sensor, based on the electrode of a chitosan-derived carbon foam, has been successfully developed for the detection of glutamate. Attributed to the chelation of Cu ions and glutamate molecules, the glutamate could be detected in an amperometric way by means of the red...

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Autores principales: Ma, Yifei, Han, Jiemin, Tong, Zhaomin, Qin, Jieling, Wang, Mei, Suhr, Jonghwan, Nam, Jaedo, Xiao, Liantuan, Jia, Suotang, Chen, Xuyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230436/
https://www.ncbi.nlm.nih.gov/pubmed/35745326
http://dx.doi.org/10.3390/nano12121987
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author Ma, Yifei
Han, Jiemin
Tong, Zhaomin
Qin, Jieling
Wang, Mei
Suhr, Jonghwan
Nam, Jaedo
Xiao, Liantuan
Jia, Suotang
Chen, Xuyuan
author_facet Ma, Yifei
Han, Jiemin
Tong, Zhaomin
Qin, Jieling
Wang, Mei
Suhr, Jonghwan
Nam, Jaedo
Xiao, Liantuan
Jia, Suotang
Chen, Xuyuan
author_sort Ma, Yifei
collection PubMed
description A non-enzymatic electrochemical sensor, based on the electrode of a chitosan-derived carbon foam, has been successfully developed for the detection of glutamate. Attributed to the chelation of Cu ions and glutamate molecules, the glutamate could be detected in an amperometric way by means of the redox reactions of chelation compounds, which outperform the traditional enzymatic sensors. Moreover, due to the large electroactive surface area and effective electron transportation of the porous carbon foam, a remarkable electrochemical sensitivity up to 1.9 × 10(4) μA/mM∙cm(2) and a broad-spectrum detection range from nM to mM scale have been achieved, which is two-orders of magnitude higher and one magnitude broader than the best reported values thus far. Furthermore, our reported glutamate detection system also demonstrates a desirable anti-interference ability as well as a durable stability. The experimental revelations show that the Cu ions chelation-assisted electrochemical sensor with carbon foam electrode has significant potential for an easy fabricating, enzyme-free, broad-spectrum, sensitive, anti-interfering, and stable glutamate-sensing platform.
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spelling pubmed-92304362022-06-25 Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions Ma, Yifei Han, Jiemin Tong, Zhaomin Qin, Jieling Wang, Mei Suhr, Jonghwan Nam, Jaedo Xiao, Liantuan Jia, Suotang Chen, Xuyuan Nanomaterials (Basel) Article A non-enzymatic electrochemical sensor, based on the electrode of a chitosan-derived carbon foam, has been successfully developed for the detection of glutamate. Attributed to the chelation of Cu ions and glutamate molecules, the glutamate could be detected in an amperometric way by means of the redox reactions of chelation compounds, which outperform the traditional enzymatic sensors. Moreover, due to the large electroactive surface area and effective electron transportation of the porous carbon foam, a remarkable electrochemical sensitivity up to 1.9 × 10(4) μA/mM∙cm(2) and a broad-spectrum detection range from nM to mM scale have been achieved, which is two-orders of magnitude higher and one magnitude broader than the best reported values thus far. Furthermore, our reported glutamate detection system also demonstrates a desirable anti-interference ability as well as a durable stability. The experimental revelations show that the Cu ions chelation-assisted electrochemical sensor with carbon foam electrode has significant potential for an easy fabricating, enzyme-free, broad-spectrum, sensitive, anti-interfering, and stable glutamate-sensing platform. MDPI 2022-06-09 /pmc/articles/PMC9230436/ /pubmed/35745326 http://dx.doi.org/10.3390/nano12121987 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Yifei
Han, Jiemin
Tong, Zhaomin
Qin, Jieling
Wang, Mei
Suhr, Jonghwan
Nam, Jaedo
Xiao, Liantuan
Jia, Suotang
Chen, Xuyuan
Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions
title Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions
title_full Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions
title_fullStr Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions
title_full_unstemmed Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions
title_short Porous Carbon Boosted Non-Enzymatic Glutamate Detection with Ultra-High Sensitivity in Broad Range Using Cu Ions
title_sort porous carbon boosted non-enzymatic glutamate detection with ultra-high sensitivity in broad range using cu ions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230436/
https://www.ncbi.nlm.nih.gov/pubmed/35745326
http://dx.doi.org/10.3390/nano12121987
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