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Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents

Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on...

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Autores principales: Asrorov, Akmal M., Muhitdinov, Bahtiyor, Tu, Bin, Mirzaakhmedov, Sharafitdin, Wang, Huiyuan, Huang, Yongzhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230553/
https://www.ncbi.nlm.nih.gov/pubmed/35744957
http://dx.doi.org/10.3390/molecules27123836
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author Asrorov, Akmal M.
Muhitdinov, Bahtiyor
Tu, Bin
Mirzaakhmedov, Sharafitdin
Wang, Huiyuan
Huang, Yongzhuo
author_facet Asrorov, Akmal M.
Muhitdinov, Bahtiyor
Tu, Bin
Mirzaakhmedov, Sharafitdin
Wang, Huiyuan
Huang, Yongzhuo
author_sort Asrorov, Akmal M.
collection PubMed
description Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on tumor cells. The development of various smart delivery systems based on enzyme drugs has been conducted for more than two decades. Some of these delivery systems have been developed to the point that they have reached clinical stages, and a few have even found application in selected cancer treatments. Various biological, chemical, and physical approaches have been utilized to enhance their efficiencies by improving their delivery and targeting. In this paper, we review advanced delivery systems for enzyme drugs for use in cancer therapy. Their structure-based functions, mechanisms of action, fused forms with other peptides in terms of targeting and penetration, and other main results from in vivo and clinical studies of these advanced delivery systems are highlighted.
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spelling pubmed-92305532022-06-25 Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents Asrorov, Akmal M. Muhitdinov, Bahtiyor Tu, Bin Mirzaakhmedov, Sharafitdin Wang, Huiyuan Huang, Yongzhuo Molecules Review Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on tumor cells. The development of various smart delivery systems based on enzyme drugs has been conducted for more than two decades. Some of these delivery systems have been developed to the point that they have reached clinical stages, and a few have even found application in selected cancer treatments. Various biological, chemical, and physical approaches have been utilized to enhance their efficiencies by improving their delivery and targeting. In this paper, we review advanced delivery systems for enzyme drugs for use in cancer therapy. Their structure-based functions, mechanisms of action, fused forms with other peptides in terms of targeting and penetration, and other main results from in vivo and clinical studies of these advanced delivery systems are highlighted. MDPI 2022-06-14 /pmc/articles/PMC9230553/ /pubmed/35744957 http://dx.doi.org/10.3390/molecules27123836 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Asrorov, Akmal M.
Muhitdinov, Bahtiyor
Tu, Bin
Mirzaakhmedov, Sharafitdin
Wang, Huiyuan
Huang, Yongzhuo
Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
title Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
title_full Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
title_fullStr Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
title_full_unstemmed Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
title_short Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
title_sort advances on delivery of cytotoxic enzymes as anticancer agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230553/
https://www.ncbi.nlm.nih.gov/pubmed/35744957
http://dx.doi.org/10.3390/molecules27123836
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