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Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230553/ https://www.ncbi.nlm.nih.gov/pubmed/35744957 http://dx.doi.org/10.3390/molecules27123836 |
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author | Asrorov, Akmal M. Muhitdinov, Bahtiyor Tu, Bin Mirzaakhmedov, Sharafitdin Wang, Huiyuan Huang, Yongzhuo |
author_facet | Asrorov, Akmal M. Muhitdinov, Bahtiyor Tu, Bin Mirzaakhmedov, Sharafitdin Wang, Huiyuan Huang, Yongzhuo |
author_sort | Asrorov, Akmal M. |
collection | PubMed |
description | Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on tumor cells. The development of various smart delivery systems based on enzyme drugs has been conducted for more than two decades. Some of these delivery systems have been developed to the point that they have reached clinical stages, and a few have even found application in selected cancer treatments. Various biological, chemical, and physical approaches have been utilized to enhance their efficiencies by improving their delivery and targeting. In this paper, we review advanced delivery systems for enzyme drugs for use in cancer therapy. Their structure-based functions, mechanisms of action, fused forms with other peptides in terms of targeting and penetration, and other main results from in vivo and clinical studies of these advanced delivery systems are highlighted. |
format | Online Article Text |
id | pubmed-9230553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-92305532022-06-25 Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents Asrorov, Akmal M. Muhitdinov, Bahtiyor Tu, Bin Mirzaakhmedov, Sharafitdin Wang, Huiyuan Huang, Yongzhuo Molecules Review Cancer is one of the most serious human diseases, causing millions of deaths worldwide annually, and, therefore, it is one of the most investigated research disciplines. Developing efficient anticancer tools includes studying the effects of different natural enzymes of plant and microbial origin on tumor cells. The development of various smart delivery systems based on enzyme drugs has been conducted for more than two decades. Some of these delivery systems have been developed to the point that they have reached clinical stages, and a few have even found application in selected cancer treatments. Various biological, chemical, and physical approaches have been utilized to enhance their efficiencies by improving their delivery and targeting. In this paper, we review advanced delivery systems for enzyme drugs for use in cancer therapy. Their structure-based functions, mechanisms of action, fused forms with other peptides in terms of targeting and penetration, and other main results from in vivo and clinical studies of these advanced delivery systems are highlighted. MDPI 2022-06-14 /pmc/articles/PMC9230553/ /pubmed/35744957 http://dx.doi.org/10.3390/molecules27123836 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Asrorov, Akmal M. Muhitdinov, Bahtiyor Tu, Bin Mirzaakhmedov, Sharafitdin Wang, Huiyuan Huang, Yongzhuo Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
title | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
title_full | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
title_fullStr | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
title_full_unstemmed | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
title_short | Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents |
title_sort | advances on delivery of cytotoxic enzymes as anticancer agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230553/ https://www.ncbi.nlm.nih.gov/pubmed/35744957 http://dx.doi.org/10.3390/molecules27123836 |
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